{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:34:27Z","timestamp":1770269667957,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T00:00:00Z","timestamp":1445558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Eur J Org Chem"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alkylation of the lithium enolate of (2<jats:italic>S<\/jats:italic>,3<jats:italic>S<\/jats:italic>,5<jats:italic>S<\/jats:italic>,6<jats:italic>S<\/jats:italic>)\u2010dimethoxy\u20102,3\u2010dimethyl\u20101,4\u2010dioxane\u20105,6\u2010dithiocarboxylate using 4\u2010benzyloxybenzyl bromide stereoselectively gave two new stereogenic centres with the carboxylate groups in a <jats:italic>cis<\/jats:italic> relationship. Hydrolytic deprotection of this intermediate produced the natural product (+)\u2010piscidic acid. Installation of a cinnamic acid ester at the secondary hydroxy group was followed by selective deprotection to give a mixture of <jats:italic>cis<\/jats:italic>\/<jats:italic>trans<\/jats:italic> cinnamates in a 3:1 ratio. Finally, the natural product cimicifugic acid L was obtained.<\/jats:p>","DOI":"10.1002\/ejoc.201501002","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T07:28:47Z","timestamp":1445585327000},"page":"7529-7533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Stereoselective Synthesis of (+)\u2010Piscidic Acid and Cimicifugic Acid L"],"prefix":"10.1002","volume":"2015","author":[{"given":"Vanessa","family":"Miranda","sequence":"first","affiliation":[]},{"given":"Christopher D.","family":"Maycock","sequence":"additional","affiliation":[]},{"given":"M. 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