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Experimental efflux studies suggested that the anion transmembrane transport activity is dependent on the receptors\u2032 lipophilicity and hydrogen bonding ability. Moreover, LUV based assays indicated that anion efflux occurs mainly through an uniport mechanism. Further MD simulations showed that anion transport is highly dependent on the orientation and interactions of the receptors at the water\/lipid interface.<\/jats:p>","DOI":"10.1002\/ejoc.202101484","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T06:34:32Z","timestamp":1640759672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Binding and Transport Properties of a Benzo[<i>b<\/i>]thiophene\u2010Based Mono\u2010(thio)urea Library"],"prefix":"10.1002","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9276-6788","authenticated-orcid":false,"given":"Cristina","family":"Moiteiro","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural Faculdade de Ci\u00eancias Universidade de Lisboa  Campo Grande 1749-016 Lisboa Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-9932","authenticated-orcid":false,"given":"Igor","family":"Marques","sequence":"additional","affiliation":[{"name":"CICECO \u2013 Aveiro Institute of Materials Department of Chemistry University of Aveiro  3810-193 Aveiro Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3299-3863","authenticated-orcid":false,"given":"William G.","family":"Ryder","sequence":"additional","affiliation":[{"name":"School of Chemistry (F11) The University of Sydney  Sydney NSW 2006 Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6428-2153","authenticated-orcid":false,"given":"Vasco","family":"Cachatra","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural Faculdade de Ci\u00eancias Universidade de Lisboa  Campo Grande 1749-016 Lisboa Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1707-8854","authenticated-orcid":false,"given":"S\u00edlvia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural Faculdade de Ci\u00eancias Universidade de Lisboa  Campo Grande 1749-016 Lisboa Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-5316","authenticated-orcid":false,"given":"Li\u2010Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry (F11) The University of Sydney  Sydney NSW 2006 Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-7121","authenticated-orcid":false,"given":"Brian J.","family":"Goodfellow","sequence":"additional","affiliation":[{"name":"CICECO \u2013 Aveiro Institute of Materials Department of Chemistry University of Aveiro  3810-193 Aveiro Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-4910","authenticated-orcid":false,"given":"Philip A.","family":"Gale","sequence":"additional","affiliation":[{"name":"School of Chemistry (F11) The University of Sydney  Sydney NSW 2006 Australia"},{"name":"The University of Sydney Nano Institute (SydneyNano) The University of Sydney  Sydney NSW 2006 Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9380-0418","authenticated-orcid":false,"given":"V\u00edtor","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"CICECO \u2013 Aveiro Institute of Materials Department of Chemistry University of Aveiro  3810-193 Aveiro Portugal"}]}],"member":"311","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04707"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00662A"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"J.\u2005M. 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