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The isotretinoin oxidation was an irreversible, diffusion\u2010controlled process, occurred in a three\u2010step cascade mechanism, and the isotretinoin diffusion coefficient D<jats:sub>13\u2010cis\u2010RA<\/jats:sub>=7.35\u00d710<jats:sup>\u22126<\/jats:sup>\u2005cm<jats:sup>2<\/jats:sup>\u2009s<jats:sup>\u22121<\/jats:sup>, was calculated. The UV\u2010Vis isotretinoin maximum absorption was pH\u2010dependent. The detection limits LOD=0.53\u2005\u03bcM, by differential pulse voltammetry, and LOD=0.38\u2005\u03bcM, by UV\u2010Vis spectroscopy, were obtained. The isotretinoin in the pharmaceutical drug Roacutan<jats:sup>\u00ae<\/jats:sup>, using differential pulse voltammetry, was determined.<\/jats:p>","DOI":"10.1002\/elan.201600206","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T05:52:46Z","timestamp":1464587566000},"page":"2709-2715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Isotretinoin Oxidation and Electroanalysis in a Pharmaceutical Drug Using a Boron\u2010doped Diamond Electrode"],"prefix":"10.1002","volume":"28","author":[{"given":"W. B. S.","family":"Machini","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Sciences and Technology University of Coimbra  3004-535 Coimbra Portugal"}]},{"given":"T. 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