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The anodic behaviour of McX is related with its chemical reducing power, and both redox properties are compared with the ones of osajaxanthone (OjX), a similar molecule with non\u2010antioxidant activity. Based on cyclic voltammetric technique, it was observed that the electrooxidation of McX at a glassy carbon electrode (GCE) is quasireversible and pH dependent, occurring easily at pH \u2265 7. The anodic behaviour of McX correlates well with its antioxidant\/reducing activity (evaluated by the DPPH method), being both redox processes attributed to the oxidation of the catechol moiety of McX. The electron transfer processes between the catechol\/o\u2010quinone redox function of McX and the GCE are simultaneously diffusion\u2010 and adsorption\u2010controlled and blocked by the adsorption of some inactive products. The achieved results are very useful for understanding and predicting the oxidative behaviour of other xanthones with biological properties. The main anodic process of McX at GCE yields a well\u2010defined and sensitive DPV response, which can be easily used for the analytical determination of this natural xanthone in real samples, namely in physiological infusions to be used in biological and clinical trials.<\/jats:p>","DOI":"10.1002\/elan.201700181","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T08:52:42Z","timestamp":1496739162000},"page":"2062-2070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Electroanalytical Study of Macluraxanthone: A Natural Product with a Strong Antioxidant and Antimalarial Activity"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-2638","authenticated-orcid":false,"given":"Jorge Ginja","family":"Teixeira","sequence":"first","affiliation":[{"name":"Chemistry Department of Science and Technology School \u00c9vora University, CLAV Rua Rom\u00e3o Ramalho n.\u25cb 59  7000-671 \u00c9vora Portugal"},{"name":"HERCULES Laboratory \u00c9vora University, Pal\u00e1cio do Vimioso Largo Marqu\u00eas de Marialva  8 7000\u2013809 \u00c9vora Portugal"}]},{"given":"Alfredina","family":"Veiga","sequence":"additional","affiliation":[{"name":"HERCULES Laboratory \u00c9vora University, Pal\u00e1cio do Vimioso Largo Marqu\u00eas de Marialva  8 7000\u2013809 \u00c9vora Portugal"}]},{"given":"Cristina Barrocas","family":"Dias","sequence":"additional","affiliation":[{"name":"Chemistry Department of Science and Technology School \u00c9vora University, CLAV Rua Rom\u00e3o Ramalho n.\u25cb 59  7000-671 \u00c9vora Portugal"},{"name":"HERCULES Laboratory \u00c9vora University, Pal\u00e1cio do Vimioso Largo Marqu\u00eas de Marialva  8 7000\u2013809 \u00c9vora Portugal"}]},{"given":"Dora Martins","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Chemistry Department of Science and Technology School \u00c9vora University, CLAV Rua Rom\u00e3o Ramalho n.\u25cb 59  7000-671 \u00c9vora Portugal"},{"name":"HERCULES Laboratory \u00c9vora University, Pal\u00e1cio do Vimioso Largo Marqu\u00eas de Marialva  8 7000\u2013809 \u00c9vora Portugal"}]}],"member":"311","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-014-1376-5"},{"key":"e_1_2_6_3_1","unstructured":"A. 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