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The development of analytical tools for non\u2010invasive detection, through the analysis of cancer biomarkers, is imperative for disease diagnosis, treatment and follow\u2010up. Tumour biomarkers refer to substances or processes that, in clinical settings, are indicative of the presence of cancer in the body. These biomarkers can be detected using biosensors, that, because of their fast, accurate and point of care applicability, are prominent alternatives to the traditional methods. Moreover, the constant innovations in the biosensing field improve the determination of normal and\/or elevated levels of tumour biomarkers in patients\u2019 biological fluids (such as serum, plasma, whole blood, urine, etc.). Although several biomarkers (DNA, RNA, proteins, cells) are known, the detection of proteins and circulating tumour cells (CTCs) are the most commonly reported due to their approval as tumour biomarkers by the specialized entities and commonly accepted for diagnosis by medical and clinical teams. Therefore, electrochemical immunosensors and cytosensors are vastly described in this review, because of their fast, simple and accurate detection, the low sample volumes required, and the excellent limits of detection obtained. The biosensing strategies reported for the six most commonly diagnosed cancers (lung, breast, colorectal, prostate, liver and stomach) are summarized and the distinct phases of the sensors\u2019 constructions (surface modification, antibody immobilization, immunochemical interactions, detection approach) and applications are discussed.<\/jats:p>","DOI":"10.1002\/elan.201800193","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T06:57:13Z","timestamp":1525071433000},"page":"1584-1603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Electrochemical Biosensing in Cancer Diagnostics and Follow\u2010up"],"prefix":"10.1002","volume":"30","author":[{"given":"Maria","family":"Freitas","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida  4200-072 Porto Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1472-8866","authenticated-orcid":false,"given":"Henri P. 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