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In addition, the synergistic effect of these compounds in cyclodextrin chiral separation was also evaluated. In comparison with most studied imidazolium\u2010based ionic liquids, several of the cations studied, are stronger modifiers in terms of electroosmotic flow (<jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content>) modulation. Phosphonium\u2010based compounds and tri\u2010octyl methylammonium chloride ([Aliquat]<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>l) had the strongest ability to reverse <jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content> both in acidic and in basic conditions and had the lowest <jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content> reversal concentrations in the presence of hydroxypropyl\u2010\u03b2\u2010cyclodextrin. <jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content> modulation ability of phosphonium cations also contributed to the improvement of chiral separation of <jats:sc>DL<\/jats:sc>\u2010propranolol by hydroxypropyl\u2010\u03b2\u2010cyclodextrin at lower concentrations in comparison with most commonly used <jats:styled-content style=\"fixed-case\">EOF<\/jats:styled-content> modulators such as tetrabutylammonium 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