{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T19:32:38Z","timestamp":1768419158176,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>A magnetic solid\u2010phase extraction (<jats:styled-content style=\"fixed-case\">MSPE<\/jats:styled-content>) method combined with capillary electrophoresis for the simultaneous determination of seven quinolones (<jats:styled-content style=\"fixed-case\">QN<\/jats:styled-content>s) (danofloxacin, ciprofloxacin, marbofloxacin, enrofloxacin, difloxacin, oxolinic acid, and flumequine), using (S)\u2010(+)\u20106\u2010methoxy\u2010\u03b1\u2010methyl\u20102\u2010naphthaleneacetic acid as internal standard, in milk samples was developed. The variables involved in the preconcentration magnetic procedure were: the composition of the magnetic support composition, the sample pH, and the weight of magnetic adsorbent used. The variables were optimized using a simplex\u2010lattice design. Different magnetite covered with octyl\u2010phenyl silica adsorbents were synthesized by varying the molar ratio of phenyltrimethylsilane and octyltrimethoxysilane; the solids were evaluated for <jats:styled-content style=\"fixed-case\">QN<\/jats:styled-content> preconcentration. Under optimal conditions, a linear range was obtained from 27 to 1000 \u03bcg L<jats:sup>\u22121<\/jats:sup> with limits of detection ranging from 9 to 12 \u03bcg L<jats:sup>\u22121<\/jats:sup> for the seven <jats:styled-content style=\"fixed-case\">QN<\/jats:styled-content>s. The absolute recoveries of the seven <jats:styled-content style=\"fixed-case\">QN<\/jats:styled-content>s at three different spiked levels (40, 150, and 400 \u03bcg L<jats:sup>\u22121<\/jats:sup>) ranged from 74% to 98% with a relative standard deviation less than 10% in all cases. The proposed method was applied to analyze 20 whole milk samples of different brands. All samples were positive for the presence of <jats:styled-content style=\"fixed-case\">QN<\/jats:styled-content> residues; in some cases, extract dilution was required. The concentrations found are in the range from 31.1 to 5047.3 \u03bcg L<jats:sup>\u22121<\/jats:sup>. Marbofloxacin was the most frequently found. The method proposed offers advantages in terms of simplicity, sensitivity, efficiency, cost, and analysis time making it an alternative for the analysis of <jats:styled-content style=\"fixed-case\">QN<\/jats:styled-content>s in whole milk samples.<\/jats:p>","DOI":"10.1002\/elps.201100559","type":"journal-article","created":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T10:11:14Z","timestamp":1342433474000},"page":"2041-2048","source":"Crossref","is-referenced-by-count":60,"title":["Determination of quinolones in milk samples using a combination of magnetic solid\u2010phase extraction and capillary electrophoresis"],"prefix":"10.1002","volume":"33","author":[{"given":"Israel S.","family":"Ibarra","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Qu\u00edmicas Universidad Aut\u00f3noma del Estado de Hidalgo  Pachuca Hgo Mexico"}]},{"given":"Jose A.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Qu\u00edmicas Universidad Aut\u00f3noma del Estado de Hidalgo  Pachuca Hgo Mexico"}]},{"given":"Ma. 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