{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T11:42:37Z","timestamp":1760528557525,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Electrophoresis"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Saliva is essential to interact with microorganisms in the oral cavity. Therefore, the interest in saliva antimicrobial properties is on the rise. Here, we used an immunoproteomic approach, based on protein separation of <jats:italic>Staphylococcus epidermidis<\/jats:italic> biofilms by 2DE, followed by Western\u2010blotting, to compare human serum and saliva reactivity profile. A total of 17 proteins were identified by MALDI\u2010TOF\/TOF. Serum and saliva presented a distinct pattern of immunoreactive proteins. Our results suggest that saliva seems to have higher propensity to react against <jats:italic>S. epidermidis<\/jats:italic> proteins with oxidoreductase activity and proteins involved with L\u2010serine metabolic processes. We show that saliva was a powerful tool for the identification of potential <jats:italic>S. epidermidis<\/jats:italic> biofilms proteins.<\/jats:p>","DOI":"10.1002\/elps.201500043","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T07:09:35Z","timestamp":1426576175000},"page":"1228-1233","source":"Crossref","is-referenced-by-count":5,"title":["Immunoreactive pattern of <i>Staphylococcus epidermidis<\/i> biofilm against human whole saliva"],"prefix":"10.1002","volume":"36","author":[{"given":"Virginia","family":"Carvalhais","sequence":"first","affiliation":[{"name":"QOPNA, Mass Spectrometry Center, Department of Chemistry University of Aveiro  Aveiro Portugal"},{"name":"CEB \u2010 Centre of Biological Engineering LIBRO \u2010 Laboratory of Research in Biofilms Ros\u00e1rio Oliveira, University of Minho  Braga Portugal"}]},{"given":"Francisco","family":"Amado","sequence":"additional","affiliation":[{"name":"QOPNA, Mass Spectrometry Center, Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"given":"Frederico","family":"Cerveira","sequence":"additional","affiliation":[{"name":"Anatomia Patol\u00f3gica, Centro Hospitalar Baixo\u2010Vouga, Avenida Artur Ravara  Aveiro Portugal"}]},{"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[{"name":"QOPNA, Mass Spectrometry Center, Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"given":"Manuel","family":"Vilanova","sequence":"additional","affiliation":[{"name":"IBMC \u2010 Instituto de Biologia Molecular e Celular  Porto Portugal"},{"name":"ICBAS \u2010 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto  Porto Portugal"}]},{"given":"Nuno","family":"Cerca","sequence":"additional","affiliation":[{"name":"IBMC \u2010 Instituto de Biologia Molecular e Celular  Porto Portugal"}]},{"given":"Rui","family":"Vitorino","sequence":"additional","affiliation":[{"name":"QOPNA, Mass Spectrometry Center, Department of Chemistry University of Aveiro  Aveiro Portugal"},{"name":"iBiMED \u2010 Institute for Biomedical Research University of Aveiro  Aveiro Portugal"}]}],"member":"311","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2004.00367.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki217"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1838"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1008"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0296-2"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2182"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004152"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(07)00008-1"},{"key":"e_1_2_3_11_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000358783","volume":"24","author":"'t H. 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