{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:44:36Z","timestamp":1776123876787,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T00:00:00Z","timestamp":1046908800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Engineering in Life Sciences"],"published-print":{"date-parts":[[2003,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This paper reports on the comparison of three modeling approaches that were applied to a fed batch evaporative sugar crystallization process. They are termed white box, black box, and grey box modeling strategies, which reflects the level of physical transparency and understanding of the model. White box models represent the traditional modeling approach, based on modeling by first principles. Black box models rely on recorded process data and knowledge collected during the normal process operation. Among various tools in this group an artificial neural networks (ANN) approach is adopted in this paper. The grey box model is obtained from a combination of first principles modeling, based on mass, energy and population balances, with an ANN to approximate three kinetic parameters \u2010\u2010 crystal growth rate, nucleation rate and the agglomeration kernel. The results have shown that the hybrid modeling approach outperformed the other aforementioned modeling strategies.<\/jats:p>","DOI":"10.1002\/elsc.200390019","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T20:28:26Z","timestamp":1048019306000},"page":"146-153","source":"Crossref","is-referenced-by-count":12,"title":["Modeling of Sugar Crystallization through Knowledge Integration"],"prefix":"10.1002","volume":"3","author":[{"given":"P.","family":"Georgieva","sequence":"first","affiliation":[]},{"given":"S.","family":"Feyo de Azevedo","sequence":"additional","affiliation":[]},{"given":"M.J.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"P.","family":"Ho","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2003,3,6]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-1354(97)87593-X"},{"key":"e_1_2_1_3_2","unstructured":"S. Chor\u00e3o S. Feyo de Azevedo A Discretized Population Balance Approach for the Modeling of Industrial Sucrose Crystallization Proc. of 13th Symp. on Industrial Crystallization Toulouse France 16\u201319 September1996 719."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-0661(99)00151-3"},{"key":"e_1_2_1_5_2","unstructured":"M. J. G. Meireles S. Feyo de Azevedo Modeling the Operation of a Sugar Industrial Evaporative Crystallizer Proc. Of Chempor 1998 Lisbon Portugal 26\u201328 September1998 807."},{"key":"e_1_2_1_6_2","first-page":"233","volume":"6","author":"Najim K.","year":"1996","journal-title":"J. Systems Eng."},{"key":"e_1_2_1_7_2","first-page":"18","volume":"96","author":"Feyo de Azevedo S.","year":"1994","journal-title":"Int. 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Wasserman Applied Linear Statistical Models McGraw\u2010Hill New York1996."}],"container-title":["Engineering in Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felsc.200390019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elsc.200390019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:59:18Z","timestamp":1760543958000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elsc.200390019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3,5]]}},"alternative-id":["10.1002\/elsc.200390019"],"URL":"https:\/\/doi.org\/10.1002\/elsc.200390019","archive":["Portico"],"relation":{},"ISSN":["1618-0240","1618-2863"],"issn-type":[{"value":"1618-0240","type":"print"},{"value":"1618-2863","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,5]]}}}