{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:50:59Z","timestamp":1760575859779,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIO\/04469\/2013"],"award-info":[{"award-number":["UID\/BIO\/04469\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Engineering in Life Sciences"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Nanoparticles of BSA and silk fibroin (SF) with entrapped \u03b1\u2010tocopherol were produced via ultrasonic emulsification. Populations with particle size of 200\u2013300\u00a0nm and highly negatively charged were obtained for all the tested formulations. Entrapment efficiencies of around 99% revealed the effective encapsulation of \u03b1\u2010tocopherol into the produced nanoformulations. Generally, these nanodevices did not induce significant cytotoxicity to human skin keratinocytes for all the concentrations tested. The developed formulations showed free radical scavenging of ABTS.<jats:sup>+<\/jats:sup> ability resulting from the synergistic effect between the proteins in formulation and the entrapped tocopherol. Overall, the results contribute for the establishment of BSA:VO and BSA:SF:VO as biodegradable and non\u2010toxic nanoformulations for the functionalization of textile devices and controlled delivery of tocopherol into the skin.<\/jats:p>","DOI":"10.1002\/elsc.201600188","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T03:29:25Z","timestamp":1477970965000},"page":"523-527","source":"Crossref","is-referenced-by-count":8,"title":["Protein\u2010based nanoformulations for \u03b1\u2010tocopherol encapsulation"],"prefix":"10.1002","volume":"17","author":[{"given":"Fatemeh Shahmoradi","family":"Ghaheh","sequence":"first","affiliation":[{"name":"Department of Textile Engineering Isfahan University of Technology  Isfahan Iran"}]},{"given":"Akbar","family":"Khoddami","sequence":"additional","affiliation":[{"name":"Department of Textile Engineering Isfahan University of Technology  Isfahan Iran"}]},{"given":"Farzaneh","family":"Alihosseini","sequence":"additional","affiliation":[{"name":"Department of Textile Engineering Isfahan University of Technology  Isfahan Iran"}]},{"given":"Andreia","family":"Gomes","sequence":"additional","affiliation":[{"name":"CBMA (Centre of Molecular and Environmental Biology), Department of Biology University of Minho, Campus of Gualtar  Braga Portugal"}]},{"given":"Artur","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centre of Biological Engineering University of Minho, Campus of Gualtar  Braga Portugal"}]},{"given":"Artur","family":"Cavaco\u2010Paulo","sequence":"additional","affiliation":[{"name":"Centre of Biological Engineering University of Minho, Campus of Gualtar  Braga Portugal"}]},{"given":"Carla","family":"Silva","sequence":"additional","affiliation":[{"name":"Centre of Biological Engineering University of Minho, Campus of Gualtar  Braga Portugal"}]}],"member":"311","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12119"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.10.1145"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02522884"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390802304222"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00408.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0010(20000515)80:7<913::AID-JSFA600>3.0.CO;2-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/10\/105606"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2015.01.060"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bfopcu.2015.10.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21553769.2012.760491"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.04.057"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp3001827"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.379"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1385\/0-89603-268-X:9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12065"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00315-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00353-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/BA20090229"}],"container-title":["Engineering in Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felsc.201600188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felsc.201600188","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elsc.201600188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:43:08Z","timestamp":1760539388000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elsc.201600188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/elsc.201600188"],"URL":"https:\/\/doi.org\/10.1002\/elsc.201600188","archive":["Portico"],"relation":{},"ISSN":["1618-0240","1618-2863"],"issn-type":[{"type":"print","value":"1618-0240"},{"type":"electronic","value":"1618-2863"}],"subject":[],"published":{"date-parts":[[2016,12,16]]}}}