{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:56:19Z","timestamp":1774288579210,"version":"3.50.1"},"reference-count":72,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Engineering in Life Sciences"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Microbial lipids have potential applications in energy, and food industry, because most of those lipids are triacylglycerol with long\u2010chain fatty\u2010acids that are comparable to conventional vegetable oils and can be obtained without arable land requirement. <jats:italic>Rhodosporidium toruloides<\/jats:italic> is a strictly aerobic strain, where oxygen plays a crucial role in growth, maintenance, and metabolite production, such as lipids and carotenoids. Dissolved oxygen concentration is one of the major factors affecting yeast physiological and biochemical characteristics. In this context, different approaches have been developed to increase available oxygen by the increasing the aeration and the addition of an oxygen\u2010vector. The growth of <jats:italic>R. toruloides<\/jats:italic> in 2\u2010L mechanical stirred tank reactor equipped with 1 or 2 porous spargers and a 70 C\/N ratio, revealed a lipid content of 0.47 and 0.52 g\/g and a lipidic productivity of 0.16 and 0.17 g\/L day, respectively. The oxygen\u2010vector addition, increased the lipidic productivity for 0.20 g\/L day and a lipid contend of 0.51 g of lipids\/g of biomass. The combined approach, combining high aeration (AA), and 1% of n\u2010dodecane addition (DA), produced a significant improvement in the lipid accumulation (62%, w\/w), when compared with the DA (51%, w\/w) and the AA (52%, w\/w) approaches. The increasing of lipids accumulation and smaller culture time are key factors for the success of scale\u2010up and profitability of a bioprocess.<\/jats:p>","DOI":"10.1002\/elsc.201800115","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T03:05:06Z","timestamp":1539313506000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A new combined approach to improved lipid production using a strictly aerobic and oleaginous yeast"],"prefix":"10.1002","volume":"19","author":[{"given":"F\u00e1bio","family":"Guerreiro","sequence":"first","affiliation":[{"name":"Center for Marine and Environmental Research\u2014CIMA University of Algarve\u2014Campus de Gambelas  Faro Portugal"}]},{"given":"Ana","family":"Constantino","sequence":"additional","affiliation":[{"name":"Center for Marine and Environmental Research\u2014CIMA University of Algarve\u2014Campus de Gambelas  Faro Portugal"}]},{"given":"Em\u00edlia","family":"Lima\u2010Costa","sequence":"additional","affiliation":[{"name":"Center for Marine and Environmental Research\u2014CIMA University of Algarve\u2014Campus de Gambelas  Faro Portugal"}]},{"given":"Sara","family":"Raposo","sequence":"additional","affiliation":[{"name":"Center for Marine and Environmental Research\u2014CIMA University of Algarve\u2014Campus de Gambelas  Faro Portugal"}]}],"member":"311","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2013.11.085"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-009-2383-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-008-0312-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2010.11.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-008-1625-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.200900078"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ef9015872"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2164(02)51000-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.33.2.231-239.1977"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.02.111"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.09.033"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2012.08.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2007.02.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2012.08.024"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2014.02.071"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-010-0704-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2006.05.019"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-1723(02)80224-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4660(199701)68:1<37::AID-JCTB601>3.0.CO;2-Y"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0734-9750(89)90900-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.260350410"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.03009.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.555680"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00172813"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00944.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1263\/jbb.105.335"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-004-0353-5"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-005-0416-2"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11172-009-0213-1"},{"key":"e_1_2_8_31_1","volume-title":"Principles of Fermentation Technology","author":"Stanbury P. F.","year":"1995"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.260460412"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60147a030"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60252a045"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2003.10.018"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2011.06.018"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002170050105"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11746-010-1672-0"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2008.06.039"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-11-71"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fuel.2007.08.007"},{"key":"e_1_2_8_43_1","unstructured":"Teresa A. M. Leveduras oleaginosaspara a produ\u00e7\u00e3o de biodiesel a partir de res\u00edduos agroindustriais. Otimiza\u00e7\u00e3o das condi\u00e7\u00f5es de crescimento e de produ\u00e7\u00e3o lip\u00eddica UAlg 2012."},{"key":"e_1_2_8_44_1","unstructured":"Val M. A influ\u00eancia das condi\u00e7\u00f5es nutricionais e operacionais na produ\u00e7\u00e3o de l\u00edpidos a partir da leveduraRhodosporidium toruloides UAlg 2013."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-010-0808-4"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2015.04.009"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2014.12.110"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2015.01.005"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/10_2008_15"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2014.07.015"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.074302-0"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2014.06.011"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2014.11.009"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/elsc.201100087"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-011-0920-2"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.201100014"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-12-26"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0255-2701(02)00067-3"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2008.10.006"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.09.017"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M400087-MCP200"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2014.09.096"},{"key":"e_1_2_8_63_1","first-page":"101","article-title":"Single cell oil production from hydrolysate of cassava starch by marine\u2010derived yeast Rhodotorula mucilaginosa TJY15a","volume":"34","author":"Li M.","year":"2010","journal-title":"BiomassBioenergy"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2010.06.153"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2014.09.113"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2014.02.017"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2013.06.047"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2014.01.022"},{"key":"e_1_2_8_69_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep04776","article-title":"Cryptococcus terricola is a promising oleaginous yeast for biodiesel production from starch through consolidated bioprocessing","volume":"4","author":"Tanimura A.","year":"2014","journal-title":"Sci. Rep."},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/en8065040"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2015.06.031"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/lite.200700091"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-8904(02)00234-0"}],"container-title":["Engineering in Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Felsc.201800115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/elsc.201800115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:35:17Z","timestamp":1760553317000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/elsc.201800115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,2]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/elsc.201800115"],"URL":"https:\/\/doi.org\/10.1002\/elsc.201800115","archive":["Portico"],"relation":{},"ISSN":["1618-0240","1618-2863"],"issn-type":[{"value":"1618-0240","type":"print"},{"value":"1618-2863","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,2]]},"assertion":[{"value":"2018-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}