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Animal\u2010derived components, including serum, coating materials, growth factors and antibodies are routinely used in cell\/tissue cultures and in general laboratory practices. In addition to ethical issues, the use and production of animal\u2010derived materials and reagents raises many scientific concerns, generally associated with presence of undefined components and batch\u2010to\u2010batch variability, which may compromise experimental reproducibility. On the other hand, non\u2010animal materials and reagents, such as human cells, alternatives to animal sera or non\u2010animal recombinant antibodies, are becoming increasingly available, and their use is encouraged by the EU Directive 2010\/63 and the Guidance Document on Good In vitro Method Practices (GIVIMP), published by the Organization for Economic Cooperation and Development (OECD). 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