{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:16:49Z","timestamp":1763036209132},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4031,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome studies performed on 3I papillary thyroid carcinomas (PTCs) revealed clonal numerical and structural abnormalities in I2 tumors. The numerical clonal aberrations found were trisomy 2, trisomy 7, and loss of the Y chromosome. A nonrandom telomeric association, tas( I5; I6)(p I3; p I3), was observed in one carcinoma. Structural alterations with a breakpoint at I0q II.2 were detected in two tumors. Other chromosomes involved in rearrangements were chromosomes I, 2, 3, 5, 7, 9, II, 12, and 14. The observation of clonal changes of chromosome 2 [i(2)(qI0) and trisomy 2] in two tumors, which were both histologically classified as tall\u2010cell PTC variants, suggests that gain of 2q may be important in the development of this morphological variant. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870130304","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:10:16Z","timestamp":1172103016000},"page":"157-162","source":"Crossref","is-referenced-by-count":24,"title":["Cytogenetic findings in 31 papillary thyroid carcinomas"],"prefix":"10.1002","volume":"13","author":[{"given":"L\u00facia","family":"Roque","sequence":"first","affiliation":[]},{"given":"Ana L.","family":"Clode","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Rosa\u2010Santos","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Soares","sequence":"additional","affiliation":[]},{"given":"S\u00e9rgio","family":"Castedo","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90118-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050306"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870040111"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890801)64:3<680::AID-CNCR2820640319>3.0.CO;2-I"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90125-R"},{"key":"e_1_2_1_7_1","first-page":"241","article-title":"Papillary carcinoma of thyroid: Classical and variants","volume":"5","author":"Chang JKC","year":"1990","journal-title":"Histol Histopathol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/32.2.6198355"},{"key":"e_1_2_1_9_1","first-page":"2549","article-title":"Overexpression of the c\u2010MET\/HGF receptor gene in human thyroid carcinomas","volume":"7","author":"Di Renzo MF","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_1_10_1","first-page":"209","article-title":"Cytogenetic analysis of a multinodular goiter","volume":"57","author":"Gama NB","year":"1991","journal-title":"Cancer Genet Cytogenet"},{"key":"e_1_2_1_11_1","first-page":"1","article-title":"Prognostic factors in thyroid carcinoma","volume":"12","author":"Hay ID","year":"1989","journal-title":"Thyroid Today"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-61383-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90253-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90154-M"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115472"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133157"},{"key":"e_1_2_1_17_1","volume-title":"Guidelines for cancer cytogenetics","author":"ISCN","year":"1991"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900915)66:6<1213::AID-CNCR2820660622>3.0.CO;2-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870060402"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90063-0"},{"key":"e_1_2_1_21_1","first-page":"6349","article-title":"Involvement of chromosome 7 in primary lung tumor and nonmalignant normal lung tissue","volume":"47","author":"Lee JS","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend-5-12-1873"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90204-N"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.5.1616"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90036-L"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90108-X"},{"key":"e_1_2_1_27_1","volume-title":"The Chromosomes in Human Cancer and Leukemia","author":"Sandberg AA","year":"1990"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90008-V"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870080202"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050307"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870090404"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90184-C"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/367319a0"},{"key":"e_1_2_1_34_1","first-page":"983","article-title":"Chromosomal analysis of sixteen human rhabdomyosarcomas","volume":"48","author":"Wang\u2010Wuu S","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.4267\/10608\/2788"},{"key":"e_1_2_1_36_1","volume-title":"Thyroid Tumors. Molecular Basis of Pathogenesis","author":"Wynford\u2010Thomas D","year":"1989"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870130304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870130304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:15:43Z","timestamp":1698365743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870130304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1002\/gcc.2870130304"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870130304","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}