{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:36:15Z","timestamp":1760297775924},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":3969,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Loss of heterozygosity (LOH) affecting the long arm of chromosome 6 has been found repeatedly in human cancers. Recently, our group reported that del(6)(q21\u201022\u2192qter) was the most consistent structural cytogenetic abnormality in gastric carcinomas. To determine more precisely the deleted region, we studied 51 tumors with 9 polymorphic markers on this chromosome arm. LOH of one or more markers was found in 39% of the tumors. LOH at region 6q22.3 was detected in 50% of informative tumors and at 6q26\u2010q27 in 37% of informative tumors. By comparative analysis of LOH regions, we identified two separate regions of overlapped deletions at 6q, one between 6q16.3\u2010q21 and 6q22.3\u2010q23.1, another distal to 6q23\u2010q24. A comparison of clinicopathologic features of gastric carcinomas with and without LOH at 6q revealed statistically significant or suggestive differences between LOH and young age of the patients and proximal location of the tumors. The two informative early gastric carcinomas both showed LOH at 6q. The occurrence of LOH at 6q was similar in all histological types. We conclude that two distinct regions at 6q appear to be involved in the early stages of gastric carcinogenesis.<\/jats:p>","DOI":"10.1002\/gcc.2870140106","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:43:24Z","timestamp":1172105004000},"page":"28-34","source":"Crossref","is-referenced-by-count":37,"title":["Identification of two distinct regions of deletion at 6q in gastric carcinoma"],"prefix":"10.1002","volume":"14","author":[{"given":"Lurdes","family":"Queimado","sequence":"first","affiliation":[]},{"given":"Raquel","family":"Seruca","sequence":"additional","affiliation":[]},{"given":"Altamiro","family":"Costa\u2010Pereira","sequence":"additional","affiliation":[]},{"given":"S\u00e9rgio","family":"Castedo","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(77)90126-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.7.3113"},{"key":"e_1_2_1_4_1","first-page":"211","article-title":"DNA content of gastric lesions with particular emphasis on gastric carcinoma","volume":"5","author":"Oavid LS","year":"1994","journal-title":"Surg Pathol"},{"key":"e_1_2_1_5_1","first-page":"1705","article-title":"Allelotype of human breast carcinoma: A second major site for loss of heterozygosity is on chromosome 6q","volume":"6","author":"Devilee P","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_6_1","first-page":"4456","article-title":"Comparison of loss of heterozygosity patterns in invasive low\u2010grade and highgrade epithelial ovarian carcinomas","volume":"53","author":"Dodson MK","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.101"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood.V80.7.1781.1781","article-title":"Deletions involving two distinct regions of 6q in B\u2010cell non\u2010Hodgkin lymphoma","volume":"8","author":"Gaidano G","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870090204"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870100202"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036288"},{"key":"e_1_2_1_13_1","volume-title":"Estat\u00edsticas da Sa\u00fade, 1991. 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