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Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte\u2010derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotransmitter release in astrocytes triggers a critical desynchronization of neural theta oscillations between dorsal hippocampus and prefrontal cortex. Moreover, we found a strong cognitive impairment in tasks depending on this network. Importantly, the supplementation with <jats:sc>d<\/jats:sc>\u2010serine completely restores hippocampal\u2013prefrontal theta synchronization and rescues the spatial memory and long\u2010term memory of dnSNARE mice. We provide here novel evidence of long distance network modulation by astrocytes, with direct implications to cognitive function.<\/jats:p>","DOI":"10.1002\/glia.23205","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T13:28:37Z","timestamp":1504877317000},"page":"1944-1960","source":"Crossref","is-referenced-by-count":100,"title":["Astrocytic signaling supports hippocampal\u2013prefrontal theta synchronization and cognitive function"],"prefix":"10.1002","volume":"65","author":[{"given":"Vanessa Morais","family":"Sardinha","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar Braga 4710\u2010057 Portugal"},{"name":"ICVS\/3B's\u2010PT Government Associate Laboratory Braga\/Guimar\u00e3es Portugal"}]},{"given":"S\u00f3nia","family":"Guerra\u2010Gomes","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School 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