{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:24:59Z","timestamp":1768587899232,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,7,21]],"date-time":"2008-07-21T00:00:00Z","timestamp":1216598400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helvetica Chimica Acta"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A simple and efficient method has been developed for the synthesis of various pyrazolo[3,4\u2010<jats:italic>d<\/jats:italic>]pyrimidines by using microwave irradiation under solvent\u2010free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X\u2010ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for <jats:italic>Botrytis.<\/jats:italic><\/jats:p>","DOI":"10.1002\/hlca.200890145","type":"journal-article","created":{"date-parts":[[2008,7,23]],"date-time":"2008-07-23T18:09:56Z","timestamp":1216836596000},"page":"1336-1345","source":"Crossref","is-referenced-by-count":23,"title":["Substituted Pyrazolo[3,4\u2010<i>d<\/i>]pyrimidines: Microwave\u2010Assisted, Solvent\u2010Free Synthesis and Biological Evaluation"],"prefix":"10.1002","volume":"91","author":[{"given":"Ana\u2005M.\u2005F.","family":"Oliveira\u2010Campos","sequence":"first","affiliation":[]},{"given":"Aravind","family":"Sivasubramanian","sequence":"additional","affiliation":[]},{"given":"L\u00edgia\u2005M.","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Julio\u2005A.","family":"Seijas","sequence":"additional","affiliation":[]},{"given":"M.","family":"Pilar\u2005V\u00e1zquez\u2010Tato","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Peixoto","sequence":"additional","affiliation":[]},{"given":"Carlos\u2005G.","family":"Abreu","sequence":"additional","affiliation":[]},{"given":"Honorina","family":"Cidade","sequence":"additional","affiliation":[]},{"given":"Ana\u2005Elizabete","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Madalena","family":"Pinto","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,7,21]]},"reference":[{"key":"e_1_2_1_1_2","unstructured":"A. Loupy"},{"key":"e_1_2_1_1_3","unstructured":"B.\u2005L. Hayes"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/p19920000311"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(00)82184-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/om00018a050"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)83996-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/00397919408020781"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00072a052"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00025a004"},{"key":"e_1_2_1_9_2","first-page":"146","author":"Villemin D.","year":"1994","journal-title":"J. Chem. Res., Synop."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00044a001"},{"key":"e_1_2_1_11_2","first-page":"20","volume":"25","author":"Seijas J. A.","year":"2007","journal-title":"Chem. Today"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1107\/S1600536806043005","volume":"62","author":"Guilardi S.","year":"2006","journal-title":"Acta Crystallogr., Sect. E: Struct. Rep. Online"},{"key":"e_1_2_1_12_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2006.04.016"},{"key":"e_1_2_1_12_4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3184\/030823404323000396","author":"Gon\u00e7alves M. S. T.","year":"2004","journal-title":"J. Chem. Res."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/a800575c"},{"key":"e_1_2_1_13_3","doi-asserted-by":"publisher","DOI":"10.3390\/90300109"},{"key":"e_1_2_1_13_4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/jm00213a014","volume":"20","author":"Kirkpatrick W. E.","year":"1977","journal-title":"J. Med. Chem."},{"key":"e_1_2_1_14_2","first-page":"752","volume":"4","author":"Filler R.","year":"1974","journal-title":"Chem. Technol."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hc.10212"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.10.053"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90245-8"},{"key":"e_1_2_1_17_3","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90310-2"},{"key":"e_1_2_1_18_2","author":"Gupta S.","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01497a043"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)00090-3"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm050136d"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/b709043a"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo01070a046"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889898007717"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0108768197018454"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2004.01.002"}],"container-title":["Helvetica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhlca.200890145","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hlca.200890145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T22:47:19Z","timestamp":1700002039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hlca.200890145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/hlca.200890145"],"URL":"https:\/\/doi.org\/10.1002\/hlca.200890145","archive":["Portico"],"relation":{},"ISSN":["0018-019X","1522-2675"],"issn-type":[{"value":"0018-019X","type":"print"},{"value":"1522-2675","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}