{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:10Z","timestamp":1761058630716},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":4213,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic analysis of short\u2010term cultures from 15 cases of benign proliferative breast disease (PBD), 10 diffuse PBD and 5 papillomas, and 15 fibroadenomas of the breast revealed clonal chromosome abnormalities in 7 diffuse PBD lesions, 4 papillomas and 5 fibroadenomas. The remaining 14 cases had a normal female chromosome complement. Cytogenetically unrelated abnormal clones were seen in 4 fibroadenomas and 2 PBDs. A single abnormal clone was found in 9 PBDs and I fibroadenoma. Three clonal abnormalities were seen as recurrent changes in 6 cases, namely interstitial deletions of 3p with 3p 12\u201314 as the minimally common deleted segment (in I papilloma, I diffuse PBD with atypia and I mixed\u2010pattern lesion with both papilloma and atypical diffuse PBD features), r(9)(p24q34) (in I diffuse PBD and I fibroadenoma), and del(l)(q12) (again in I diffuse PBD and I fibroadenoma). Intriguingly, 6 of the 16 abnormal cases had chromosome changes that have been seen repeatedly as primary abnormalities in breast carcinomas: der(16)t(l;16)(q10;p10), del(3)(p12p14), and del(l)(q12). We conclude that some of the chromosome anomalies frequently found in breast carcinomas are also present in PBD and fibroadenomas. These aberrations may be accepted as early, neoplasia\u2010relevant mutations. However, they do not seem to be sufficient by themselves to unleash a malignant process. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910600107","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:42:20Z","timestamp":1171932140000},"page":"49-53","source":"Crossref","is-referenced-by-count":72,"title":["Chromosome abnormalities in benign hyperproliferative disorders of epithelial and stromal breast tissue"],"prefix":"10.1002","volume":"60","author":[{"given":"Claudia U.","family":"Dietrich","sequence":"first","affiliation":[]},{"given":"Nikos","family":"Pandis","sequence":"additional","affiliation":[]},{"given":"Manuel R.","family":"Teixeira","sequence":"additional","affiliation":[]},{"given":"Georgia","family":"Bardi","sequence":"additional","affiliation":[]},{"given":"Anne\u2010Marie","family":"Gerdes","sequence":"additional","affiliation":[]},{"given":"Johan A.","family":"Andersen","sequence":"additional","affiliation":[]},{"given":"Sverre","family":"Heim","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"171","article-title":"Etude cytog\u00e9n\u00e9tique comparative de sept carcinomes d'origine mammaire","volume":"20","author":"Ayraud N.","year":"1977","journal-title":"Ann. 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