{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:46:44Z","timestamp":1791805604390,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2021QH1126"],"award-info":[{"award-number":["2021QH1126"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insulin resistance and chronic inflammation each predict cardiovascular mortality, but they are usually studied separately. The C\u2010reactive protein\u2013triglyceride glucose index (CTI) combines both, yet its prognostic value in postmenopausal women, who experience concurrent rises in insulin resistance and inflammation, remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We identified postmenopausal women from the National Health and Nutrition Examination Survey (NHANES) (1999\u20132018;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097007) and the China Health and Retirement Longitudinal Study (CHARLS) (2011;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094235). CTI\u2009=\u20090.412\u2009\u00d7\u2009ln [hs\u2010CRP (mg\/L)]\u2009+\u2009ln[(fasting triglycerides \u00d7 fasting glucose)\/2]. The endpoint was all\u2010cause mortality. We fitted Cox models, restricted cubic splines (RCS), and piecewise regression with likelihood ratio tests for threshold detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median 9.0\u2009years (CHARLS) and 11.9\u2009years (NHANES), 2940 deaths occurred (26.2%). Each 1\u2010unit CTI increase carried a 28% higher mortality hazard after full adjustment (hazard ratio [HR] 1.28; 95% confidence interval [CI] 1.20\u20131.35;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The dose\u2013response was nonlinear in NHANES (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) but linear in CHARLS (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.14). In NHANES, a threshold emerged at CTI\u2009=\u20095.43: above it, per\u2010unit HR\u2009=\u20091.85 (95% CI 1.62\u20132.11); below, HR\u2009=\u20090.99 (95% CI 0.89\u20131.10;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.87). The highest versus lowest tertile HRs were 1.51 (1.16\u20131.97) in CHARLS and 1.35 (1.22\u20131.49) in NHANES. Excluding baseline cancer cases did not change the results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher CTI predicts greater all\u2010cause mortality in postmenopausal women. In the US cohort, risk rose sharply, above CTI\u2009=\u20095.43. The same trend in the Chinese cohort, although linear, suggests that CTI might be a useful risk marker across populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71373","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:06:39Z","timestamp":1791803199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["C\u2010reactive protein\u2013triglyceride glucose index and all\u2010cause mortality in postmenopausal women: A dual\u2010cohort study from the National Health and Nutrition Examination Survey and the China Health and Retirement Longitudinal Study"],"prefix":"10.1002","author":[{"given":"Ruihong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics the Second Affiliated Hospital of Fujian Medical University  Quanzhou China"},{"name":"The Second Clinical Medical College Fujian Medical University  Quanzhou 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Medical University  Quanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihuang","family":"Zhuang","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Fujian Medical University  Quanzhou China"},{"name":"Department of Hematology the Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2202-8456","authenticated-orcid":false,"given":"Lvxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics the Second Affiliated Hospital of Fujian Medical University  Quanzhou China"},{"name":"The Second Clinical Medical College Fujian Medical University  Quanzhou 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