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As the use of these substances has been spread as an alternative to the classic illicit psychostimulants, such as amphetamines, their legal status was reviewed, resulting in an utter prohibition of these NPS in many countries worldwide. Herein, the prevalence of abuse, chemistry, biological effects, metabolism, and the potential harms and risky behaviors associated with the abuse of benzofurans are reviewed. The congeners of this group are mainly consumed recreationally at electronic dance music parties, in polydrug abuse settings. Benzofurans preferentially act by disturbing the functioning of serotonergic circuits, which induces their entactogenic and stimulant effects and is the reason behind the considerable number of recent <jats:italic>benzo fury<\/jats:italic>\u2010related deaths. The slight interaction of these drugs with the dopaminergic system justifies the rewarding effects of these drugs. To date, published evidence on the mechanisms of toxicity of <jats:italic>benzo fury<\/jats:italic> is very limited but a body of research is now beginning to emerge revealing an alarming public health threat regarding the abuse of these NPS.<\/jats:p>","DOI":"10.1002\/jat.3774","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T21:20:36Z","timestamp":1549401636000},"page":"1083-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>Benzo fur<\/i>y: A new trend in the drug misuse scene"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2257-6903","authenticated-orcid":false,"given":"Rita","family":"Roque Bravo","sequence":"first","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy University of Porto  Rua Jorge Viterbo Ferreira, 228 Porto 4050\u2010313 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-5285","authenticated-orcid":false,"given":"Helena","family":"Carmo","sequence":"additional","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy University of Porto  Rua Jorge Viterbo Ferreira, 228 Porto 4050\u2010313 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-3494","authenticated-orcid":false,"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy University of Porto  Rua Jorge Viterbo Ferreira, 228 Porto 4050\u2010313 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-503X","authenticated-orcid":false,"given":"Maria de Lourdes","family":"Bastos","sequence":"additional","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy University of Porto  Rua Jorge Viterbo Ferreira, 228 Porto 4050\u2010313 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7331-9157","authenticated-orcid":false,"given":"Diana","family":"Dias da Silva","sequence":"additional","affiliation":[{"name":"UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy University of Porto  Rua Jorge Viterbo Ferreira, 228 Porto 4050\u2010313 Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2014.10.016"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkw018"},{"key":"e_1_2_13_4_1","unstructured":"Advisory Council on the Misuse of Drugs(2013).Benzofurans: A review of the evidence of use and harm. 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