{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:40:32Z","timestamp":1694598032836},"reference-count":42,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Council for Technological and Scientific Development (CNPq)","award":["311078\/2015-0","305905\/2014-7","305739\/2014-0"],"award-info":[{"award-number":["311078\/2015-0","305905\/2014-7","305739\/2014-0"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES\/PROSUP)","award":["1182788"],"award-info":[{"award-number":["1182788"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biophotonics"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>The treatment for oral cancer usually involves surgical excision followed by chemotherapy and\/or radiotherapy. The combination of these therapies generally promotes a serious inflammation of the mucosa of the digestive tract, denominated mucositis, which compromises continuity of treatment. Photobiomodulation (PBM) therapy has been used successfully to reduce the oral mucositis, however there is still some controversy regarding the effects of this therapy on unintentionally irradiated tumor cells that may remain after cancer treatment. The aim of this study was to analyze the effect of PBM therapy (using parameters for mucositis) on the modulation of osteoclastogenic potential of a cell line derived from human lingual squamous cell carcinoma (SCC9). Previously irradiated SCC9 cells were co\u2010cultured with human osteoclast precursors. Co\u2010cultures performed with non\u2010irradiated SCC9 cells served as control. After 7, 14 and 21 days the co\u2010cultures were evaluated for the tartrate\u2010resistant acid phosphatase (TRAP) activity, an osteoclastogenic marker. Additionally, the monocultures of SCC9 cells (non\u2010irradiated and irradiated) were analyzed for cell viability\/proliferation and for the expression of IL\u201011 and PTHrP. The irradiation of SCC9 cells with PBM with an energy density of 4\u00a0J\/cm<jats:sup>2<\/jats:sup> decreased the pro\u2010osteoclastogenic potential of those cells. This may represent a potential useful side effect of PBM therapy.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:caption><jats:p>PBM (using recommended parameters for mucositis treatment) decreases the osteoclastogenic potential of oral squamous carcinoma cells.<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/jbio201500292-gra-0001-m.png\"><jats:alt-text>magnified image<\/jats:alt-text><jats:caption><jats:p>PBM (using recommended parameters for mucositis treatment) decreases the osteoclastogenic potential of oral squamous carcinoma cells.<\/jats:p><\/jats:caption><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/jbio.201500292","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T16:56:01Z","timestamp":1460998561000},"page":"1136-1147","source":"Crossref","is-referenced-by-count":7,"title":["Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells"],"prefix":"10.1002","volume":"9","author":[{"given":"Tatiana","family":"Dias Schalch","sequence":"first","affiliation":[{"name":"Biophotonics Applied to Health Sciences Postgraduate Program Nove de Julho University \u2013 UNINOVE  235\/249 Vergueiro Street 01504\u2010001 S\u00e3o Paulo Brazil"}]},{"given":"Kristianne","family":"Porta Santos Fernandes","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Postgraduate Program Nove de Julho University \u2013 UNINOVE  235\/249 Vergueiro Street 01504\u2010001 S\u00e3o Paulo Brazil"}]},{"given":"Jo\u00e3o","family":"Costa\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory for Bone Metabolism and Regeneration, Faculdade de Medicina Dent\u00e1ria Universidade do Porto, Portugal  Dr. Manuel Pereira da Silva Street 4200\u2010393 Porto Portugal"}]},{"given":"M\u00f4nica","family":"Pereira Garcia","sequence":"additional","affiliation":[{"name":"Laboratory for Bone Metabolism and Regeneration, Faculdade de Medicina Dent\u00e1ria Universidade do Porto, Portugal  Dr. Manuel Pereira da Silva Street 4200\u2010393 Porto Portugal"}]},{"given":"Raquel","family":"Agnelli Mesquita\u2010Ferrari","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Postgraduate Program Nove de Julho University \u2013 UNINOVE  235\/249 Vergueiro Street 01504\u2010001 S\u00e3o Paulo Brazil"}]},{"given":"Sandra","family":"Kalil Bussadori","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Postgraduate Program Nove de Julho University \u2013 UNINOVE  235\/249 Vergueiro Street 01504\u2010001 S\u00e3o Paulo Brazil"}]},{"given":"Maria Helena","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratory for Bone Metabolism and Regeneration, Faculdade de Medicina Dent\u00e1ria Universidade do Porto, Portugal  Dr. Manuel Pereira da Silva Street 4200\u2010393 Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"663","volume":"20","author":"Deyama Y.","year":"2008","journal-title":"Oncol Rep"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn045"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00793.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.09.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.01.005"},{"key":"e_1_2_6_7_1","first-page":"404","volume":"56","author":"Iguchi H.","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01781.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90229-5"},{"key":"e_1_2_6_10_1","first-page":"18","volume":"19","author":"Guise T. 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