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Using this method that relies only on thickness and collimated transmittance measurements, the diffusion properties of glycerol, fructose, polypropylene glycol and water in muscle tissues were evaluated. Amongst other results, the diffusion coefficient of glycerol in colorectal muscle was estimated with a value of 3.3 \u00d7 10<jats:sup>\u22127<\/jats:sup> cm<jats:sup>2<\/jats:sup>\/s. 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