{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:11:46Z","timestamp":1769238706913,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T00:00:00Z","timestamp":1314057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Helicobacter pylori (H. pylori<\/jats:italic>) is one of the most common infectious agents in the world and it is thought to colonize the gastric mucosa of about half of the world's population causing several gastric diseases. In this work, the effect of surface chemistry on <jats:italic>H. pylori<\/jats:italic> nonspecific adhesion, viability, and morphology was evaluated using three <jats:italic>H. pylori<\/jats:italic> strains with different adhesins expression profile. Self\u2010assembled monolayers (SAMs) of alkanethiols on gold were used to obtain surfaces exposing different functional groups: OH, CH3, and ethylene glycol (EG4). Bacterial adhesion onto the surfaces reached a plateau at 2 h. There was a correlation between adhesion and the exposed surface group, with bacterial cells adhering preferentially to CH3\u2010SAMs while EG4\u2010SAMs prevented <jats:italic>H. pylori<\/jats:italic> adhesion during the entire adhesion test (24 h). Surfaces that presented the EG4 group were also the only ones that significantly reduced the viability of adhered bacteria. Surface chemistry also influenced the morphology of adhered bacteria. The <jats:italic>H. pylori<\/jats:italic> rod shape observed in the control (Tissue Culture Polyethylene\u2014TCPE) was only retrieved on CH3\u2010SAMs. This work demonstrates that surface chemistry, namely specific functional groups on the material, influence the nonspecific adsorption of <jats:italic>H. pylori<\/jats:italic>. Moreover, the features of the bacterial strain and the surface chemistry can alter the adhesion kinetics, as well as the morphology and viability of attached bacteria. \u00a9 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.<\/jats:p>","DOI":"10.1002\/jbm.a.33178","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T21:57:38Z","timestamp":1314827858000},"page":"344-353","source":"Crossref","is-referenced-by-count":54,"title":["Effect of surface chemistry on bacterial adhesion, viability, and morphology"],"prefix":"10.1002","volume":"99A","author":[{"given":"Paula","family":"Parreira","sequence":"first","affiliation":[]},{"given":"Ana","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"In\u00eas C.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Vidal","sequence":"additional","affiliation":[]},{"given":"Celso A.","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Deborah E.","family":"Leckband","sequence":"additional","affiliation":[]},{"given":"M. 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