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However, the lack of bioactivity on Ti surfaces is still a major concern regarding the osseointegration process. It is known that the rapid recruitment of osteoblasts in bone defects is an essential prerequisite for efficient bone repair. Conventionally, osteoblast recruitment to bone defects and subsequent bone repair has been achieved using growth factors. Thus, in this study highly porous Ti samples were processed by powder metallurgy using space holder technique followed by the bio\u2010functionalization through microarc oxidation using a Ca\u2010 and P\u2010rich electrolyte. The biological response in terms of early cell response, namely, adhesion, spreading, viability, and proliferation of the novel biofunctionalized highly porous Ti was carried out with NIH\/3T3 fibroblasts and MC3T3\u2010E1 preosteoblasts in terms of viability, adhesion, proliferation, and alkaline phosphatase activity. Results showed that bio\u2010functionalization did not affect the cell viability. However, bio\u2010functionalized highly porous Ti (22% porosity) enhanced the cell proliferation and activity. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 73\u201385, 2019.<\/jats:p>","DOI":"10.1002\/jbm.b.34096","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T04:22:53Z","timestamp":1520569373000},"page":"73-85","source":"Crossref","is-referenced-by-count":28,"title":["Influence of macroporosity on NIH\/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3\u2010E1 over bio\u2010functionalized highly porous titanium implant material"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-9083","authenticated-orcid":false,"given":"A. 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