{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:25:54Z","timestamp":1761017154665},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003946","name":"European Society for Sexual Medicine","doi-asserted-by":"publisher","award":["ESSM Award for Medical Research 2011"],"award-info":[{"award-number":["ESSM Award for Medical Research 2011"]}],"id":[{"id":"10.13039\/501100003946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label \/><jats:p>Erectile dysfunction (ED) is a complication of diabetes, condition responsible for causing endothelial dysfunction (EDys) and hampering repair mechanisms. However, scarce information is available linking vasculogenesis mediated by Endothelial Progenitor Cells (EPCs) and diabetes\u2010associated ED. Furthermore, it remains to be elucidated if glycemic control plays a role on EPCs functions, EPCs modulators, and penile vascular health. We evaluated the effects of diabetes and insulin therapy on bone marrow (BM) and circulating EPCs, testosterone, and systemic\/penile Stromal Derived Factor\u20101 alpha (SDF\u20101\u03b1) expression. Male Wistar rats were divided into groups: age\u2010matched controls, 8\u2010weeks streptozotocin\u2010induced type 1 diabetics, and insulin\u2010treated 8\u2010weeks diabetics. EPCs were identified by flow cytometry for CD34\/CD133\/VEGFR2\/CXCR4 antigens. Systemic SDF\u20101\u03b1 and testosterone levels were evaluated by ELISA. Penile SDF\u20101\u03b1 protein expression was assessed, in experimental and human diabetic cavernosal samples, by immunohistochemical techniques. Diabetic animals presented a reduction of BM\u2010derived EPCs and an increase in putative circulating endothelial cells (CECs) sloughed from vessels wall. These alterations were rescued by insulin therapy. In addition, glycemic control promoted an increase in systemic testosterone and SDF\u20101\u03b1 levels, which were significantly decreased in animals with diabetes. SDF\u20101\u03b1 protein expression was reduced in experimental and human cavernosal diabetic samples, an effect prevented by insulin in treated animals. Insulin administration rescued the effects of diabetes on BM function, CECs levels, testosterone, and plasmatic\/penile SDF\u20101\u03b1 protein expression. This emphasizes the importance of glycemic control in the prevention of diabetes\u2010induced systemic and penile EDys, by the amelioration of endothelial damage, and increase in protective pathways. J. Cell. Biochem. 118: 82\u201391, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcb.25613","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T11:36:44Z","timestamp":1464608204000},"page":"82-91","source":"Crossref","is-referenced-by-count":10,"title":["Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Control?"],"prefix":"10.1002","volume":"118","author":[{"given":"Angela","family":"Castela","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Biochemistry University of Porto Porto Portugal"},{"name":"Institute for Molecular and Cell Biology of the University of Porto (IBMC\u2010UP) Porto Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade Universidade do Porto Porto Portugal"}]},{"given":"Pedro","family":"Gomes","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology (CNC) University of Coimbra Coimbra 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