{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:00:09Z","timestamp":1772848809427,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,9]],"date-time":"2004-02-09T00:00:00Z","timestamp":1076284800000},"content-version":"vor","delay-in-days":3418,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Chemical Tech &amp;amp; Biotech"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Penicillin\u2010G fermentation with industrial media in 1 m<jats:sup>3<\/jats:sup> stirred tank bioreactors was studied. A model based on the Bajpai\u2013Reuss model structure was developed. Under typical production conditions catabolite repression is nonidentifiable and extensive mycelium differentiation occurs. Thus, the original model was reformulated, neglecting glucose repression of penicillin production and including biomass autolysis. The multi\u2010substrate nature of industrial media was critically analysed. By combining the two most important carbon substrates present, a simple and applicable model was obtained. Model predictions agreed well with experimental data and reproduced the general characteristics observed in the fermentations. The predictive power of the model was tested for fermentations with different sugar feed rate profiles and raw materials (corn\u2010steep liquor and sugar syrup). Several aspects of parameter estimation and model development are discussed on the basis of direct experimental data inspection and a sensitivity analysis of model parameters.<\/jats:p>","DOI":"10.1002\/jctb.280610207","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T11:29:42Z","timestamp":1117279782000},"page":"123-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Mathematical modelling of industrial pilot\u2010plant penicillin\u2010G fed\u2010batch fermentations"],"prefix":"10.1002","volume":"61","author":[{"given":"Jos\u00e9 C.","family":"Menezes","sequence":"first","affiliation":[]},{"given":"Sebasti\u00e3o S.","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o M.","family":"Lemos","sequence":"additional","affiliation":[]},{"given":"Sebasti\u00e3o Feyo","family":"de Azevedo","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,2,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"45","volume-title":"Biotechnology of Industrial Antiobiotics","author":"Hersbach G. 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