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Three electronic databases were searched up to September 30, 2021 to identify randomized controlled trials that involved the treatment of single GRD without interproximal tissue loss via root coverage procedures. A frequentist NMA was conducted for complete root coverage (CRC), mean root coverage (MRC), and keratinized tissue width (KTW) changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 38 studies reporting on 830 patients and 1,265 GRD were included. SCTG + CAF was ranked as the most efficient treatment approach for MRC, CRC, and KTW gain at 6 and 12 months after surgery, except for MRC at the 12\u2010month follow\u2010up where enamel matrix derivative plus CAF exhibited superior results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SCTG + CAF can be considered the gold standard for the treatment of single GRD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jper.22-0167","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T03:39:51Z","timestamp":1650598791000},"page":"1336-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Does the subepithelial connective tissue graft in conjunction with a coronally advanced flap remain as the gold standard therapy for the treatment of single gingival recession defects? 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