{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:40:06Z","timestamp":1773081606806,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2004,4,2]],"date-time":"2004-04-02T00:00:00Z","timestamp":1080864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this contribution, a new separation method for simultaneous determination of paracetamol, caffeine, acetylsalicylic acid, and internal standard benzoic acid was developed based on a novel reversed\u2010phase sequential injection chromatography (SIC) technique with UV detection. A Chromolith\u00ae Flash RP\u201018e, 25\u20104.6 mm column (Merck, Germany) and a FIAlab\u00ae 3000 system (USA) with an 8\u2010port selection valve and a 5 mL syringe were used for sequential injection chromatographic separations in our study. The mobile phase used was acetonitrile\u2010(0.01 M) phosphate buffer (10\u00a0:\u00a090, <jats:italic>v\/v<\/jats:italic>) pH 4.05, flow rate 0.6 mL min<jats:sup>\u20131<\/jats:sup>. UV detection was at 210 and 230 nm. The validation parameters showed good results: linearity (<jats:italic>r<\/jats:italic> &gt;0.999) for all compounds, detection limits in the range 0.3\u20130.8 \u03bcg mL<jats:sup>\u20131<\/jats:sup>, repeatability (RSD) of peak heights between runs in the range 1.10\u20134.30% at three concentration levels and intra\u2010day repeatability of the retention times in the range 0.28\u20130.43%. The analysis time was &lt;\u00a06 min. The method was found to be applicable for the routine analysis of the active compounds paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets.<\/jats:p>","DOI":"10.1002\/jssc.200301644","type":"journal-article","created":{"date-parts":[[2004,4,2]],"date-time":"2004-04-02T06:01:34Z","timestamp":1080885694000},"page":"529-536","source":"Crossref","is-referenced-by-count":67,"title":["Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets"],"prefix":"10.1002","volume":"27","author":[{"given":"Dalibor","family":"\u0160at\u00ednsk\u00fd","sequence":"first","affiliation":[]},{"given":"Isabel","family":"Neto","sequence":"additional","affiliation":[]},{"given":"Petr","family":"Solich","sequence":"additional","affiliation":[]},{"given":"Hana","family":"Sklen\u00e1\u0159ov\u00e1","sequence":"additional","affiliation":[]},{"given":"M.","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[]},{"given":"B. 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