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The purpose of this work was to develop a simple methodology, using direct injection of the samples, by HPLC with diode array detection (DAD), for a multiresidue analysis of five antibiotics of different classes. Wastewater from an urban water treatment plant was selected as a model to study possible coelution of interfering compounds. The linearity interval ranged from 40 to 400 \u03bcg\/L for amoxicillin (Amox), metronidazole (Metro), cefazolin (Cefa), and chloramphenicol (Chloram) and from 20 to 200 \u03bcg\/L for sulfamethoxazole (Sulfa), with LODs lower than 14 \u03bcg\/L. Repeatability, expressed by the CV of six repeated injections, ranged from 1 to 8%, while the intermediate precision varied between 2 and 11%. The recovery ranged from 90 to 109%. This method enables the fast screening of a large number of samples, with an expanded uncertainty in the 1\u201322% range. The advantage of the proposed method is to significantly reduce the number of samples to be analyzed by more complex methods.<\/jats:p>","DOI":"10.1002\/jssc.200800229","type":"journal-article","created":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T08:31:57Z","timestamp":1221035517000},"page":"2924-2931","source":"Crossref","is-referenced-by-count":32,"title":["Fast screening procedure for antibiotics in wastewaters by direct HPLC\u2010DAD analysis"],"prefix":"10.1002","volume":"31","author":[{"given":"Salom\u00e9","family":"Teixeira","sequence":"first","affiliation":[]},{"given":"Cristina","family":"Delerue\u2010Matos","sequence":"additional","affiliation":[]},{"given":"Arminda","family":"Alves","sequence":"additional","affiliation":[]},{"given":"L\u00facia","family":"Santos","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,9,10]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2007.01.008"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.02.038"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2006.11.014"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2004.08.097"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00041-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/es049509a"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2006.11.035"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.08.027"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1128\/AEM.64.9.3499-3502.1998","volume":"64","author":"Guardabassi L.","year":"1998","journal-title":"Appl. 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