{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:14:54Z","timestamp":1761513294555,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T00:00:00Z","timestamp":1369612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ci\u00eancia e a Tecnologia (FCT), Portugal","award":["SFRH\/BPD\/76974\/2011","PTDC\/AGR-CFL\/102597\/2008"],"award-info":[{"award-number":["SFRH\/BPD\/76974\/2011","PTDC\/AGR-CFL\/102597\/2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Synthetic musks are organic compounds used as fragrance additives and fixative compounds in a diversity of personal care products. A new method based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction followed by <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> for the analysis of 12 musks in personal care products was developed and validated. Some experimental parameters, such as total <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>u<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>h<jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content> mass, sample mass\/solvent volume ratio, type of extraction solvent, as well as salts and sorbents amount were investigated and optimized. The final method involves the musks extraction using acetonitrile, followed by the addition of anhydrous magnesium sulphate and sodium acetate. The clean\u2010up step was performed using dispersive <jats:styled-content style=\"fixed-case\">SPE<\/jats:styled-content> with primary and secondary amine and octadecyl\u2013silica sorbents. This extraction procedure is fast (about 10 min) when compared to other traditional approaches. The method was robust for the matrices studied and shows a high precision (%RSD &lt; 15%) and accuracy (average recovery of 85%), allowing the detection of musks in minimum concentrations between 0.01 ng\/g (galaxolide) and 15.80 ng\/g (musk xylene). The developed method was applied to the analysis of 12 samples, which revealed musks concentrations ranging from 2 ng\/g (toothpaste) to 882\u00a0340 ng\/g (perfumed body lotion).<\/jats:p>","DOI":"10.1002\/jssc.201300190","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T04:43:03Z","timestamp":1366951383000},"page":"2176-2184","source":"Crossref","is-referenced-by-count":25,"title":["New analytical method for the determination of musks in personal care products by <scp>Q<\/scp>uick, <scp>E<\/scp>asy, <scp>C<\/scp>heap, <scp>E<\/scp>ffective, <scp>R<\/scp>ugged, and <scp>S<\/scp>afe extraction followed by <scp>GC<\/scp>\u2013<scp>MS<\/scp>"],"prefix":"10.1002","volume":"36","author":[{"given":"Vera","family":"Homem","sequence":"first","affiliation":[{"name":"LEP\u00c6, Faculdade de Engenharia Universidade do Porto Porto Portugal"}]},{"given":"Jos\u00e9","family":"Avelino Silva","sequence":"additional","affiliation":[{"name":"LEP\u00c6, Faculdade de 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