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The method involves simultaneous derivatization and extraction of compounds by dispersive liquid\u2013liquid microextraction followed by gas chromatography with mass spectrometry analysis. Derivatization and extraction parameters were optimized with the aid of experimental design approach. An excellent linear response was achieved for all analytes (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> \u2265 0.999). Limits of detection and quantification are 0.003\u20130.005 and 0.0094\u20130.0164 \u03bcg\/L, respectively. Intraday precision ranged between 1.1 and 12.6%, whereas interday precision ranged between 0.5 and 14.7%. For accuracy, bias values varied between \u201315.0 and 13.7%. Recoveries at three concentration levels ranged from 86.4 to 118.2%. The proposed method can be applied to the routine analysis of groundwater, river, sea, tap, and mineral water samples with excellent sensitivity, precision, and accuracy.<\/jats:p>","DOI":"10.1002\/jssc.201401463","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T02:44:23Z","timestamp":1427597063000},"page":"1983-1989","source":"Crossref","is-referenced-by-count":5,"title":["Application of a fast and cost\u2010effective in situ derivatization method prior to gas chromatography with mass spectrometry to monitor endocrine disruptors in water matrices"],"prefix":"10.1002","volume":"38","author":[{"given":"Armindo","family":"Melo","sequence":"first","affiliation":[{"name":"REQUIMTE\/Departamento de Ci\u00eancias Qu\u00edmicas, Laborat\u00f3rio de Bromatologia e Hidrologia Faculdade de Farm\u00e1cia\u2014Universidade do Porto  Portugal"},{"name":"Departamento de Sa\u00fade Ambiental Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge  Porto Portugal"}]},{"given":"Isabel M. 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