{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:45:30Z","timestamp":1769607930381,"version":"3.49.0"},"reference-count":211,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies have reported a human papillomavirus (HPV) prevalence of 20% to 30% in laryngeal squamous cell carcinoma (LSCC), although clinical data on HPV involvement remain largely inconsistent, ascribed by some to differences in HPV detection methods or in geographic origin of the studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To perform a systematic review and formal meta\u2010analysis of the literature reporting on HPV detection in LSCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature was searched from January 1964 until March 2015. The effect size was calculated as event rates (95% confidence interval [CI]), with homogeneity testing using Cochran's Q and<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>statistics. Meta\u2010regression was used to test the impact of study\u2010level covariates (HPV detection method, geographic origin) on effect size. Potential publication bias was estimated using funnel plot symmetry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred seventy nine studies were eligible, comprising a sample size of 7,347 LSCCs from different geographic regions. Altogether, 1,830 (25%) cases tested HPV\u2010positive considering all methods, with effect size of 0.269 (95% CI: 0.242 to 0.297; random\u2010effects model). In meta\u2010analysis stratified by the 1) HPV detection technique and 2) geographic study origin, the between\u2010study heterogeneity was significant only for geographic origin (<jats:italic>P<\/jats:italic>= .0001). In meta\u2010regression, the HPV detection method (<jats:italic>P<\/jats:italic>= .876) or geographic origin (<jats:italic>P<\/jats:italic>= .234) were not significant study\u2010level covariates. Some evidence for publication bias was found only for studies from North America and those using non\u2013polymerase chain reaction methods, with a marginal effect on adjusted point estimates for both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Variability in HPV detection rates in LSCC is explained by geographic origin of study but not by HPV detection method. However, they were not significant study\u2010level covariates in formal meta\u2010regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>NA<jats:italic>Laryngoscope<\/jats:italic>, 126:885\u2013893, 2016<\/jats:p><\/jats:sec>","DOI":"10.1002\/lary.25738","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T09:55:15Z","timestamp":1446803715000},"page":"885-893","source":"Crossref","is-referenced-by-count":66,"title":["Detection of human papillomavirus in laryngeal squamous cell carcinoma: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"126","author":[{"given":"Ricardo Ribeiro","family":"Gama","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Head and Neck Surgery, Barretos Cancer Hospital Barretos Brazil"}]},{"given":"Andr\u00e9 Lopes","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Head and Neck Surgery, Barretos Cancer Hospital Barretos Brazil"}]},{"given":"Adhemar Longatto","family":"Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation (LIM) 14 Department of Pathology University of S\u00e3o Paulo School of Medicine S\u00e3o Paulo Brazil"},{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho Braga Portugal"},{"name":"ICVS\/3B's\u2013PT Government Associate Laboratory Braga\/Guimar\u00e3es Portugal"},{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital Barretos Brazil"}]},{"given":"Anderson Paulo","family":"Scorsato","sequence":"additional","affiliation":[{"name":"Department of Bioestatistics Barretos Cancer Hospital Barretos Brazil"}]},{"given":"Rossana V. 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