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We compiled thousands of bulk stable isotope measurements (carbon and nitrogen) of brown trout (\n                    <jats:italic>Salmo trutta<\/jats:italic>\n                    ,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092854) and Arctic charr (\n                    <jats:italic>Salvelinus alpinus<\/jats:italic>\n                    ,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093062) from 120 cold\u2010water lakes across northern Europe, spanning 0.02 to 1090\u2009km\n                    <jats:sup>2<\/jats:sup>\n                    in size, to quantify the relative importance of nine potential drivers of energy and nutrient flows. Fish community type and individual body size matched the well\u2010described ecologies of the two species: charr shifted from littoral to pelagic sources with interspecific competition, and trout opportunistically increased their trophic position with piscivorous prey availability and increasing body size. The anthropogenic impacts of water\u2010level regulation and catchment modification were mirrored in the two species, resulting in decreased \u03b4\n                    <jats:sup>13<\/jats:sup>\n                    C values, implying increased relative pelagic production in regulated lakes, and increased \u03b4\n                    <jats:sup>15<\/jats:sup>\n                    N values, possibly due to increasing cross\u2010boundary nutrient flows. Lake size and climatic drivers (summer precipitation and winter temperature) elicited strong species\u2010specific changes in isotope values, suggesting that predator\u2010driven ecological responses can dominate over ecosystem\u2010wide changes in energy and nutrient flows within lake food webs. No isotopic trends were observed with catchment productivity or shoreline complexity at the regional scale, contrasting with insights from local scale studies. This spatial mismatch suggests that environmental drivers of ecosystem processes playing out at the regional scale cannot necessarily be extrapolated from localized studies, despite correlated random lake effects capturing unexplained local baseline shifts in isotopes.\n                  <\/jats:p>","DOI":"10.1002\/lno.70333","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:00:39Z","timestamp":1772964039000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional ecosystem responses to environmental drivers in cold\u2010water lakes evaluated using stable isotopes of salmonid fishes"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-3986","authenticated-orcid":false,"given":"Matthew R. 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