{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T13:38:06Z","timestamp":1775050686937,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T00:00:00Z","timestamp":1128470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2005,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Summary:<\/jats:bold> Hydroxypropyl chitosan\u2010<jats:italic>graft<\/jats:italic>\u2010carboxymethyl <jats:italic>\u03b2<\/jats:italic>\u2010cyclodextrin (HPCH\u2010<jats:italic>g<\/jats:italic>\u2010CM <jats:italic>\u03b2<\/jats:italic>\u2010CD) was synthesized by grafting CM <jats:italic>\u03b2<\/jats:italic>\u2010CD onto HPCH using water soluble 1\u2010ethyl\u20103\u2010(3\u2010dimethylaminopropyl)carbodiimide (EDC) as the condensing agent. Due to the presence of hydrophobic <jats:italic>\u03b2<\/jats:italic>\u2010CD rings onto the HPCH backbone, this polymer can be used as a matrix for controlled drug release. The adsorption of a hydrophobic model drug, ketoprofen, by HPCH\u2010<jats:italic>g<\/jats:italic>\u2010CM <jats:italic>\u03b2<\/jats:italic>\u2010CD microparticles (using tripolyphosphate as an ionic crosslinking agent) fitted well in the Langmuir isotherm equation. The drug dissolution profile showed that HPCH\u2010<jats:italic>g<\/jats:italic>\u2010CM <jats:italic>\u03b2<\/jats:italic>\u2010CD microparticles provided a slower release of the entrapped ketoprofen than chitosan, and the release behavior was influenced by the pH value of the medium. These results suggest that <jats:italic>\u03b2<\/jats:italic>\u2010CD grafted with chitosan derivatives may become a potential biodegradable delivery system to control the release of hydrophobic drugs with pH\u2010responsive capability.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:caption><jats:p>The structure and drug release profiles of HPCH\u2010<jats:italic>g<\/jats:italic>\u2010CM <jats:italic>\u03b2<\/jats:italic>\u2010CD.<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/gif\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mgra001.gif\"><jats:alt-text>magnified image<\/jats:alt-text><jats:caption><jats:p>The structure and drug release profiles of HPCH\u2010<jats:italic>g<\/jats:italic>\u2010CM <jats:italic>\u03b2<\/jats:italic>\u2010CD.<\/jats:p><\/jats:caption><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p>","DOI":"10.1002\/mabi.200500087","type":"journal-article","created":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T15:49:03Z","timestamp":1128527343000},"page":"965-973","source":"Crossref","is-referenced-by-count":91,"title":["Hydroxypropyl Chitosan Bearing <i>\u03b2<\/i>\u2010Cyclodextrin Cavities: Synthesis and Slow Release of its Inclusion Complex with a Model Hydrophobic Drug"],"prefix":"10.1002","volume":"5","author":[{"given":"Mani","family":"Prabaharan","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o F.","family":"Mano","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,10,5]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023007032444"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr970022c"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr970015o"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr960371r"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr970014w"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr970025p"},{"key":"e_1_2_6_7_2","first-page":"26","volume":"9","author":"Loftsson T.","year":"1997","journal-title":"Pharm. 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