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The hydrogels based on polysaccharides incorporated with thermo\u2010responsive polymers have shown unique properties such as biocompatibility, biodegradability, and biological functions in addition to the stimuli\u2010responsive characters. These \u201csmart\u201d hydrogels exhibit single or multiple stimuli\u2010responsive characters which could be used in biomedical applications, including controlled drug delivery, bioengineering or tissue engineering. This review focuses on the recent developments and future trends dealing with stimuli\u2010responsive hydrogels based on grafting\/blending of polysaccharides such as chitosan, alginate, cellulose, dextran and their derivatives with thermo\u2010sensitive polymers. This review also screens the current applications of these hydrogels in the fields of drug delivery, tissue engineering and wound healing.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:caption><jats:p>Synthesis scheme for the SA\/PNIPAAm semi\u2010IPN hydrogel.<\/jats:p><\/jats:caption><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/gif\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mgra001.gif\"><jats:alt-text>magnified image<\/jats:alt-text><jats:caption><jats:p>Synthesis scheme for the SA\/PNIPAAm semi\u2010IPN hydrogel.<\/jats:p><\/jats:caption><\/jats:graphic><\/jats:boxed-text>\n<\/jats:p>","DOI":"10.1002\/mabi.200600164","type":"journal-article","created":{"date-parts":[[2006,11,24]],"date-time":"2006-11-24T14:32:51Z","timestamp":1164378771000},"page":"991-1008","source":"Crossref","is-referenced-by-count":311,"title":["Stimuli\u2010Responsive Hydrogels Based on Polysaccharides Incorporated with Thermo\u2010Responsive Polymers as Novel Biomaterials"],"prefix":"10.1002","volume":"6","author":[{"given":"Mani","family":"Prabaharan","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o F.","family":"Mano","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,11,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma011362"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma035838w"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm049349v"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.12.019"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/B406727D"},{"key":"e_1_2_9_6_2","volume-title":"Controlled Drug Delivery, Challenge and Strategies","author":"Bae Y. 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