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The melt\u2010based approach used to produce the scaffolds does not change their main characteristics, including the surface roughness and microporosity. The porosity, pore size, interconnectivity and mechanical performance of the scaffolds are all within the range required for various tissue\u2010engineering applications. Biological assessments are performed in direct\u2010contact assays. Cells are able to colonize the scaffold, including the inner porous structure. The cells show high indices of viability in all of the scaffold types.<\/jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/jpeg\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mgra001.jpg\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/mabi.201000011","type":"journal-article","created":{"date-parts":[[2010,8,30]],"date-time":"2010-08-30T01:08:13Z","timestamp":1283130493000},"page":"1495-1504","source":"Crossref","is-referenced-by-count":19,"title":["Melt Processing of Chitosan\u2010Based Fibers and Fiber\u2010Mesh Scaffolds for the Engineering of Connective Tissues"],"prefix":"10.1002","volume":"10","author":[{"given":"Vitor M.","family":"Correlo","sequence":"first","affiliation":[]},{"given":"Ana R.","family":"Costa\u2010Pinto","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Sol","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 A.","family":"Covas","sequence":"additional","affiliation":[]},{"given":"Mrinal","family":"Bhattacharya","sequence":"additional","affiliation":[]},{"given":"Nuno M.","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2010,8,26]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00078.x"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02706447"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.24"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.801"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2005.12.007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.02.046"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820270104"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820270207"},{"key":"e_1_2_6_9_2","first-page":"OP260","volume":"14","author":"Pashkuleva I.","year":"2008","journal-title":"Tissue Eng. 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