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Toward this goal, a novel micro\u2010droplet generator is developed to produce microcapsules. Microcapsules with an average diameter of 500\u2009\u00b5m, smooth surface, and homogeneous size distribution are obtained. ATDC5\u2009cells encapsulated in carboxymethyl xanthan (CMX) microcapsules remain viable and are observed to proliferate for prolonged culture periods with enhanced metabolic activity. Furthermore, retention of the chondrogenic phenotype is exhibited by the cells within CMX, suggesting the ability of this material to be applied in cell\u2010delivery therapies.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/jpeg\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mgra001.jpg\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/mabi.201100304","type":"journal-article","created":{"date-parts":[[2011,12,24]],"date-time":"2011-12-24T23:47:54Z","timestamp":1324770474000},"page":"350-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Encapsulation and Survival of a Chondrocyte Cell Line within Xanthan Gum Derivative"],"prefix":"10.1002","volume":"12","author":[{"given":"Ana C.","family":"Mendes","sequence":"first","affiliation":[]},{"given":"Erkan T.","family":"Baran","sequence":"additional","affiliation":[]},{"given":"Rui C.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Helena S.","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2011,12,23]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2005.05.004"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001000600001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6776628"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.08.034"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00073-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.01.014"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2007.07.010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2009.08.008"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.07.240"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10370"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0801"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.08.042"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.186"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.05.083"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.08.010"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00053-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.04.009"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1659"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.145"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90027-7"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.07.002"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199808)176:2<303::AID-JCP8>3.0.CO;2-S"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.08.032"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050673"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-3910(97)00180-8"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0734-9750(00)00050-1"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0144-8617(95)00092-5"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2007.01.048"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-3861(97)00079-7"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0144-8617(99)00156-3"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.184"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1sm05594a"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.2.457"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.117"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0922-3371(90)90079-C"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1247\/csf.25.195"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05873"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0144-8617(03)00051-1"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2005.02.025"},{"key":"e_1_2_6_40_2","unstructured":"E. 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