{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:27:58Z","timestamp":1760549278929},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2012,7,16]],"date-time":"2012-07-16T00:00:00Z","timestamp":1342396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanisms associated with the cellular internalization of nanomedicines must be carefully considered when designing drug\u2010 and vaccine\u2010delivery systems. The cellular fate and effects of nanomedicines depend to a large extent on the cell uptake routes. A self\u2010assembled mannan nanogel is developed as a vaccination platform for antigen and adjuvant delivery. The mannan nanogel uptake by murine bone\u2010marrow\u2010derived macrophages is found to be time\u2010, concentration\u2010, and energy\u2010dependent, involving mannose\u2010receptor\u2010mediated phagocytosis and clathrin\u2010mediated endocytosis. The nanogel is also visualized in the cytosol suggesting endolysosomal escape. These results indicate that mannan nanogel is a promising versatile carrier for intracellular delivery of vaccines or therapeutic agents.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/jpeg\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mgra001.jpg\"><jats:alt-text>magnified image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/mabi.201200075","type":"journal-article","created":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T04:50:49Z","timestamp":1342500649000},"page":"1172-1180","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unraveling the Uptake Mechanisms of Mannan Nanogel in Bone\u2010Marrow\u2010Derived Macrophages"],"prefix":"10.1002","volume":"12","author":[{"given":"S\u00edlvia A.","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Alexandra","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Madureira","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Vilanova","sequence":"additional","affiliation":[]},{"given":"Francisco M.","family":"Gama","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2012,7,16]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.05.044"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2006.443"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200800123"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2008.30"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm900266r"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp087"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32648"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.01.036"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031253"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(88)90033-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0053-z"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.065"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/b821583a"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2007.09.002"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.19"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(01)02082-7"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080474"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2122"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201003086"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.03.038"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.02.003"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.30501.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.01.018"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0088com"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.07.023"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2011.05.020"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90376-2"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4049\/jimmunol.134.2.982","volume":"134","author":"Warren M. K.","year":"1985","journal-title":"J. Immunol."},{"key":"e_1_2_6_29_2","author":"Zhang X.","year":"2008","journal-title":"Curr. Protoc. Immunol."},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.05.023"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.7.3730"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01559.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.3.759"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.103.038422"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-71331-9_5"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.07002"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00133.2008"},{"key":"e_1_2_6_39_2","first-page":"19","author":"Zinchuk V.","year":"2008","journal-title":"Curr. Protoc. Cell Biol."},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00462.2010"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.103.3.857"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1993.tb03313.x"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000016249.52831.a5"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.08.111"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.03.031"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.09.006"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801763105"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.19.111401.093127"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.6.1785"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270941"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270942"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00090-6"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200006)30:6<1714::AID-IMMU1714>3.0.CO;2-C"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524013363645"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260219"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0153-3"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.2.389"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.127.5.1217"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-007-0376-5"},{"key":"e_1_2_6_60_2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1242\/jcs.107.4.933","volume":"107","author":"Wagner M.","year":"1994","journal-title":"J. Cell Sci."},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00284-3"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.05.003"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201200075","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201200075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201200075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:39:41Z","timestamp":1697445581000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201200075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,16]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1002\/mabi.201200075"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201200075","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,16]]}}}