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The present study is conducted to characterize this bioengineered protein\u2010based biomaterial further for in vivo behavior related to biocompatibility. 6mer\u2009+\u2009BSP protein films are implanted in subcutaneous pouches in the back of mice and responses are evaluated by flow cytometry and histology. The results show no major differences between the inflammatory responses induced by 6mer\u2009+\u2009BSP films and the responses observed for the controls. 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