{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:15:06Z","timestamp":1770506106299,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":734,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:label\/><jats:p>A self\u2010assembled glycol chitosan nanogel (GC) is synthesized by chemically grafting hydrophobic chains onto a polysaccharide, which is comprehensively characterized. The obtained macromolecular micelle is decorated with folate\u2010conjugated poly(ethylene glycol) (PEG) (GCFA). An average size distribution of 250 and 200\u2009nm is observed, respectively for the GC and GCFA nanogels. Differential cell localization is observed on incubating the materials with HeLa cells. Whereas the GC nanogel is detected on the cell surface, GCFA is localized in the cytoplasm. The cell viability is not compromised by the nanogels. Interestingly, GC nanogel is poorly internalized by bone marrow derived macrophages (BMDMs), and GCFA is not phagocytosed. Given its ability to complex siRNA, the targetable GC nanogel can be a promising vehicle for siRNA delivery.<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mabi201300123-gra-0001.png\" xlink:title=\"mabi201300123-gra-0001\"\/><\/jats:p><\/jats:sec>","DOI":"10.1002\/mabi.201300123","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T12:12:46Z","timestamp":1377691966000},"page":"1369-1378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Glycol Chitosan\u2010<scp>B<\/scp>ased Nanogel as a Potential Targetable Carrier for siRNA"],"prefix":"10.1002","volume":"13","author":[{"given":"Paula","family":"Pereira","sequence":"first","affiliation":[{"name":"Institute for Biotechnology and Bioengineering (IBB) Centre for Biological Engineering Campus de Gualtar University of Minho Braga Portugal"}]},{"given":"Daniela","family":"Morgado","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1 Ing\u00e9ni\u00e9rie des Mat\u00e9riaux Polym\u00e8res (IMP@Lyon1), CNRS UMR 5223, 15 Bd Latarjet 69622 Villeurbanne Cedex France"}]},{"given":"Agn\u00e8s","family":"Crepet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1 Ing\u00e9ni\u00e9rie des Mat\u00e9riaux Polym\u00e8res (IMP@Lyon1), CNRS UMR 5223, 15 Bd Latarjet 69622 Villeurbanne Cedex France"}]},{"given":"Laurent","family":"David","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1 Ing\u00e9ni\u00e9rie des Mat\u00e9riaux Polym\u00e8res (IMP@Lyon1), CNRS UMR 5223, 15 Bd Latarjet 69622 Villeurbanne Cedex France"}]},{"given":"Francisco M.","family":"Gama","sequence":"additional","affiliation":[{"name":"Institute for Biotechnology and Bioengineering (IBB) Centre for Biological Engineering Campus de Gualtar University of Minho Braga Portugal"}]}],"member":"311","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.08.004"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.08.023"},{"key":"e_1_2_6_4_1","first-page":"19","volume-title":"Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering Chitosan","author":"Riva R.","year":"2011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/187221109787158346"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.03.076"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.02.023"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.093229"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/19\/04\/045102"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.08.046"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.09.023"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/la0350608"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.12.013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2009.09.007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.23125"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.031922-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1998.tb06185.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000012156.65125.01"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.10.002"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.04.009"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31430"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(03)00155-9"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00299352"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-011-4302-y"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2007.06.008"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2005.04.109"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp984620m"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp026479u"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/la200552k"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.04.021"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2007.07.012"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.09.004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(96)04847-8"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.08.112"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2010.04.090"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2009.09.024"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2010.12.042"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.06.015"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030899"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.11.012"}],"updated-by":[{"DOI":"10.1002\/mabi.201400150","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000}}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201300123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201300123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:36:51Z","timestamp":1696354611000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201300123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/mabi.201300123"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201300123","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]},"assertion":[{"value":"2013-08-28","name":"published_online","label":"Published Online","group":{"name":"publication_history","label":"Publication History"}}]}}