{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:44:29Z","timestamp":1762641869338,"version":"3.41.0"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/CVT\/102972\/2008"],"award-info":[{"award-number":["PTDC\/CVT\/102972\/2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Biosci."],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1002\/mabi.201600141","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T12:39:56Z","timestamp":1470227996000},"page":"1662-1677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Development of an Injectable Calcium Phosphate\/Hyaluronic Acid Microparticles System for Platelet Lysate Sustained Delivery Aiming Bone Regeneration"],"prefix":"10.1002","volume":"16","author":[{"given":"Pedro S.","family":"Babo","sequence":"first","affiliation":[{"name":"3B's Research Group; Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine; AvePark Zona Industrial da Gandra 4805-017 Barco GMR Portugal"}]},{"given":"V\u00edtor E.","family":"Santo","sequence":"additional","affiliation":[{"name":"3B's Research Group; Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine; AvePark Zona Industrial da Gandra 4805-017 Barco GMR Portugal"}]},{"given":"Manuela E.","family":"Gomes","sequence":"additional","affiliation":[{"name":"3B's Research Group; Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine; AvePark Zona Industrial da Gandra 4805-017 Barco GMR Portugal"}]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[{"name":"3B's Research Group; Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine; AvePark Zona Industrial da Gandra 4805-017 Barco GMR Portugal"}]}],"member":"311","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"10.1002\/mabi.201600141-BIB0001|mabi201600141-cit-0001","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1016\/j.biomaterials.2006.05.022","volume":"27","author":"Link","year":"2006","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0002|mabi201600141-cit-0002","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1016\/j.biomaterials.2011.08.005","volume":"32","author":"Felix Lanao","year":"2011","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0003|mabi201600141-cit-0003","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.biomaterials.2007.10.029","volume":"29","author":"Link","year":"2008","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0004|mabi201600141-cit-0004","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.jbiomech.2012.02.004","volume":"45","author":"Larsson","year":"2012","journal-title":"J. Biomech."},{"key":"10.1002\/mabi.201600141-BIB0005|mabi201600141-cit-0005","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/term.1514","volume":"8","author":"Oortgiesen","year":"2014","journal-title":"J. Tissue Eng. Regener. Med."},{"key":"10.1002\/mabi.201600141-BIB0006|mabi201600141-cit-0006","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/term.59","volume":"1","author":"Plachokova","year":"2007","journal-title":"J. Tissue Eng. Regener. Med."},{"key":"10.1002\/mabi.201600141-BIB0007|mabi201600141-cit-0007","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1016\/j.biomaterials.2004.09.023","volume":"26","author":"Fernandez","year":"2005","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0008|mabi201600141-cit-0008","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4161\/cam.2.1.5884","volume":"2","author":"Lawrence","year":"2008","journal-title":"Cell Adhes. Migr."},{"key":"10.1002\/mabi.201600141-BIB0009|mabi201600141-cit-0009","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1016\/j.msec.2013.04.042","volume":"33","author":"Ko","year":"2013","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1002\/mabi.201600141-BIB0010|mabi201600141-cit-0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.curtheres.2013.05.002","volume":"75","author":"Bolukbasi","year":"2013","journal-title":"Curr. Ther. Res."},{"key":"10.1002\/mabi.201600141-BIB0011|mabi201600141-cit-0011","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/jor.21152","volume":"28","author":"Jungbluth","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1002\/mabi.201600141-BIB0012|mabi201600141-cit-0012","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jebdp.2011.12.003","volume":"12","author":"Fu","year":"2012","journal-title":"J. Evidence-Based Dent. Pract."},{"key":"10.1002\/mabi.201600141-BIB0013|mabi201600141-cit-0013","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.arthro.2010.03.002","volume":"26","author":"Sanchez","year":"2010","journal-title":"Arthroscopy"},{"key":"10.1002\/mabi.201600141-BIB0014|mabi201600141-cit-0014","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1054\/jcms.2002.0285","volume":"30","author":"Weibrich","year":"2002","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"10.1002\/mabi.201600141-BIB0015|mabi201600141-cit-0015","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3727\/096368910X543376","volume":"20","author":"Crespo-Diaz","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1002\/mabi.201600141-BIB0016|mabi201600141-cit-0016","doi-asserted-by":"crossref","first-page":"e40831","DOI":"10.1371\/journal.pone.0040831","volume":"7","author":"Phipps","year":"2012","journal-title":"PloS One"},{"key":"10.1002\/mabi.201600141-BIB0017|mabi201600141-cit-0017","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/j.1537-2995.2007.01220.x","volume":"47","author":"Schallmoser","year":"2007","journal-title":"Transfusion"},{"key":"10.1002\/mabi.201600141-BIB0018|mabi201600141-cit-0018","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.athoracsur.2011.04.084","volume":"92","author":"Kurita","year":"2011","journal-title":"Ann. Thorac. Surg."},{"key":"10.1002\/mabi.201600141-BIB0019|mabi201600141-cit-0019","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.actbio.2012.01.016","volume":"8","author":"Matsui","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1002\/mabi.201600141-BIB0020|mabi201600141-cit-0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/scrt277","volume":"4","author":"Pham","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1002\/mabi.201600141-BIB0021|mabi201600141-cit-0021","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.blre.2009.04.001","volume":"23","author":"Blair","year":"2009","journal-title":"Blood Rev."},{"key":"10.1002\/mabi.201600141-BIB0022|mabi201600141-cit-0022","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2012.06.001","volume":"162","author":"Santo","year":"2012","journal-title":"J. Controlled Release"},{"key":"10.1002\/mabi.201600141-BIB0023|mabi201600141-cit-0023","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.biomaterials.2009.09.043","volume":"31","author":"Chevallier","year":"2010","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0024|mabi201600141-cit-0024","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2010.10.021","volume":"149","author":"Chen","year":"2011","journal-title":"J. Controlled Release"},{"key":"10.1002\/mabi.201600141-BIB0025|mabi201600141-cit-0025","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1021\/bm800051m","volume":"9","author":"Sahoo","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1002\/mabi.201600141-BIB0026|mabi201600141-cit-0026","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.cellbio.23.090506.123337","volume":"23","author":"Jiang","year":"2007","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1002\/mabi.201600141-BIB0027|mabi201600141-cit-0027","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/S0142-9612(98)00042-8","volume":"19","author":"Campoccia","year":"1998","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0028|mabi201600141-cit-0028","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-3659(97)00242-3","volume":"53","author":"Prestwich","year":"1998","journal-title":"J. Controlled Release"},{"key":"10.1002\/mabi.201600141-BIB0029|mabi201600141-cit-0029","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0142-9612(03)00467-8","volume":"25","author":"Yun","year":"2004","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0030|mabi201600141-cit-0030","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1021\/bc9701095","volume":"8","author":"Vercruysse","year":"1997","journal-title":"Bioconjugate Chem."},{"key":"10.1002\/mabi.201600141-BIB0031|mabi201600141-cit-0031","first-page":"25","volume-title":"Hylan Gel for Soft-Tissue Augmentation","author":"Larsen","year":"1994"},{"key":"10.1002\/mabi.201600141-BIB0032|mabi201600141-cit-0032","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/bm049508a","volume":"6","author":"Burdick","year":"2005","journal-title":"Biomacromolecules"},{"key":"10.1002\/mabi.201600141-BIB0033|mabi201600141-cit-0033","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1365-2796.1997.00173.x","volume":"242","author":"Gerdin","year":"1997","journal-title":"J. Intern. Med."},{"key":"10.1002\/mabi.201600141-BIB0034|mabi201600141-cit-0034","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1021\/acs.biomac.5b00168","volume":"16","author":"Isa","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1002\/mabi.201600141-BIB0035|mabi201600141-cit-0035","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1126\/science.2408340","volume":"228","author":"West","year":"1985","journal-title":"Science"},{"key":"10.1002\/mabi.201600141-BIB0036|mabi201600141-cit-0036","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2796.1997.00171.x","volume":"242","author":"Toole","year":"1997","journal-title":"J. Intern. Med."},{"key":"10.1002\/mabi.201600141-BIB0037|mabi201600141-cit-0037","unstructured":"P. S. Babo R. L. Reis M. E. Gomes J Biomater Appl 2016"},{"key":"10.1002\/mabi.201600141-BIB0038|mabi201600141-cit-0038","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0142-9612(03)00467-8","volume":"25","author":"Yun","year":"2004","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0039|mabi201600141-cit-0039","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-3659(97)00242-3","volume":"53","author":"Prestwich","year":"1998","journal-title":"J. Controlled Release"},{"key":"10.1002\/mabi.201600141-BIB0040|mabi201600141-cit-0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0304-3835(98)00195-5","volume":"131","author":"Menzel","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1002\/mabi.201600141-BIB0041|mabi201600141-cit-0041","first-page":"235","volume":"20","author":"Zavan","year":"2009","journal-title":"J. Mater. Sci."},{"key":"10.1002\/mabi.201600141-BIB0042|mabi201600141-cit-0042","doi-asserted-by":"crossref","first-page":"s47","DOI":"10.1002\/term.1519","volume":"6","author":"Santo","year":"2012","journal-title":"J. Tissue Eng. Regener. Med."},{"key":"10.1002\/mabi.201600141-BIB0043|mabi201600141-cit-0043","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2492\/inflammregen.34.033","volume":"34","author":"Babo","year":"2014","journal-title":"Inflammation Regener."},{"key":"10.1002\/mabi.201600141-BIB0044|mabi201600141-cit-0044","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1016\/j.biomaterials.2006.04.043","volume":"27","author":"Yeo","year":"2006","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0045|mabi201600141-cit-0045","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1021\/bc9701095","volume":"8","author":"Vercruysse","year":"1997","journal-title":"Bioconjugate Chem."},{"key":"10.1002\/mabi.201600141-BIB0046|mabi201600141-cit-0046","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.biomaterials.2012.10.008","volume":"34","author":"Dahlmann","year":"2013","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0047|mabi201600141-cit-0047","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jbm.b.31619","volume":"94","author":"Low","year":"2010","journal-title":"J. Biomed. Mater. Res., Part B"},{"key":"10.1002\/mabi.201600141-BIB0048|mabi201600141-cit-0048","first-page":"353","volume":"18","author":"del Valle","year":"2007","journal-title":"J. Mater. Sci."},{"key":"10.1002\/mabi.201600141-BIB0049|mabi201600141-cit-0049","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1016\/j.biomaterials.2006.08.013","volume":"27","author":"Otsuki","year":"2006","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0050|mabi201600141-cit-0050","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.addr.2006.09.007","volume":"58","author":"Arifin","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1002\/mabi.201600141-BIB0051|mabi201600141-cit-0051","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3109\/14653249.2012.655420","volume":"14","author":"Fekete","year":"2012","journal-title":"Cytotherapy"},{"key":"10.1002\/mabi.201600141-BIB0052|mabi201600141-cit-0052","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biomaterials.2015.01.020","volume":"48","author":"Oliveira","year":"2015","journal-title":"Biomaterials"},{"key":"10.1002\/mabi.201600141-BIB0053|mabi201600141-cit-0053","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1083\/jcb.92.2.584","volume":"92","author":"Seppa","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1002\/mabi.201600141-BIB0054|mabi201600141-cit-0054","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF02820501","volume":"6","author":"Kieswetter","year":"1997","journal-title":"Endocrine"},{"key":"10.1002\/mabi.201600141-BIB0055|mabi201600141-cit-0055","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.2106\/JBJS.D.02752","volume":"87","author":"Ranly","year":"2005","journal-title":"J. Bone Jt. Surg."},{"key":"10.1002\/mabi.201600141-BIB0056|mabi201600141-cit-0056","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jbm.b.31525","volume":"92","author":"Cui","year":"2010","journal-title":"J. Biomed. Mater. Res., Part B"},{"key":"10.1002\/mabi.201600141-BIB0057|mabi201600141-cit-0057","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0021-9290(03)00257-4","volume":"37","author":"Bayraktar","year":"2004","journal-title":"J. Biomech."},{"key":"10.1002\/mabi.201600141-BIB0058|mabi201600141-cit-0058","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1089\/ten.2006.0015","volume":"13","author":"Link","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1002\/mabi.201600141-BIB0059|mabi201600141-cit-0059","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1002\/mabi.201600141-BIB0060|mabi201600141-cit-0060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/ten.tea.2009.0164","volume":"16","author":"Frohlich","year":"2010","journal-title":"Tissue Eng., Part A"},{"key":"10.1002\/mabi.201600141-BIB0061|mabi201600141-cit-0061","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.archoralbio.2007.12.007","volume":"53","author":"Tanne","year":"2008","journal-title":"Arch. Oral Biol."},{"key":"10.1002\/mabi.201600141-BIB0062|mabi201600141-cit-0062","first-page":"118","volume":"15","author":"Lian","year":"1995","journal-title":"Iowa Orthop. J."},{"key":"10.1002\/mabi.201600141-BIB0063|mabi201600141-cit-0063","doi-asserted-by":"crossref","first-page":"33132","DOI":"10.1074\/jbc.M500608200","volume":"280","author":"Gaur","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mabi.201600141-BIB0064|mabi201600141-cit-0064","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1359\/jbmr.2003.18.2.213","volume":"18","author":"Shui","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1002\/mabi.201600141-BIB0065|mabi201600141-cit-0065","doi-asserted-by":"crossref","first-page":"36181","DOI":"10.1074\/jbc.M206057200","volume":"277","author":"Xiao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mabi.201600141-BIB0066|mabi201600141-cit-0066","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cytogfr.2009.10.010","volume":"20","author":"Song","year":"2009","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1002\/mabi.201600141-BIB0067|mabi201600141-cit-0067","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/jcb.10467","volume":"88","author":"Yagi","year":"2003","journal-title":"J. Cell. Biochem."}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201600141","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/mabi.201600141\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T12:06:29Z","timestamp":1749038789000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201600141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,2]]},"references-count":67,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"URL":"https:\/\/doi.org\/10.1002\/mabi.201600141","archive":["Portico"],"relation":{},"ISSN":["1616-5187"],"issn-type":[{"type":"print","value":"1616-5187"}],"subject":[],"published":{"date-parts":[[2016,8,2]]}}}