{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T18:57:10Z","timestamp":1774724230659,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"DOI":"10.13039\/501100000886","name":"Directorate-General for Regional Policy","doi-asserted-by":"publisher","award":["0687_NOVOMAR_1_P"],"award-info":[{"award-number":["0687_NOVOMAR_1_P"]}],"id":[{"id":"10.13039\/501100000886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC\u20102012\u2010ADG 20120216\u2010321266"],"award-info":[{"award-number":["ERC\u20102012\u2010ADG 20120216\u2010321266"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/102471\/2014"],"award-info":[{"award-number":["SFRH\/BD\/102471\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/100627\/2014"],"award-info":[{"award-number":["SFRH\/BPD\/100627\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00376\/2014"],"award-info":[{"award-number":["IF\/00376\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00373\/2014"],"award-info":[{"award-number":["IF\/00373\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00032\/2013"],"award-info":[{"award-number":["IF\/00032\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI\u201001\u20100145\u2010FEDER\u2010007679"],"award-info":[{"award-number":["POCI\u201001\u20100145\u2010FEDER\u2010007679"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["FCT UID\/CTM\/50011\/2013"],"award-info":[{"award-number":["FCT UID\/CTM\/50011\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/QUI\/00062\/2013"],"award-info":[{"award-number":["UID\/QUI\/00062\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["PT2020"],"award-info":[{"award-number":["PT2020"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000886","name":"Directorate-General for Regional Policy","doi-asserted-by":"publisher","award":["0687_NOVOMAR_1_P"],"award-info":[{"award-number":["0687_NOVOMAR_1_P"]}],"id":[{"id":"10.13039\/501100000886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013276","name":"INTERREG","doi-asserted-by":"crossref","award":["2007-2013\/POCTEP"],"award-info":[{"award-number":["2007-2013\/POCTEP"]}],"id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CarbPol_u_Algae","award":["EXPL\/MAR-BIO\/0165\/2013"],"award-info":[{"award-number":["EXPL\/MAR-BIO\/0165\/2013"]}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2012-ADG 20120216-321266"],"award-info":[{"award-number":["ERC-2012-ADG 20120216-321266"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Research Council"},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/102471\/2014"],"award-info":[{"award-number":["SFRH\/BD\/102471\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/100627\/2014"],"award-info":[{"award-number":["SFRH\/BPD\/100627\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00376\/2014"],"award-info":[{"award-number":["IF\/00376\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00373\/2014"],"award-info":[{"award-number":["IF\/00373\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00032\/2013"],"award-info":[{"award-number":["IF\/00032\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007679"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007679"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["FCT UID\/CTM\/50011\/2013"],"award-info":[{"award-number":["FCT UID\/CTM\/50011\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/QUI\/00062\/2013"],"award-info":[{"award-number":["UID\/QUI\/00062\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["PT2020"],"award-info":[{"award-number":["PT2020"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromolecular Bioscience"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>There is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine\u2010origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0.2 mg mL<jats:sup>\u22121<\/jats:sup>), despite similarities in sulfation degree and carbohydrates composition. Although the three FEs present different molecular weights, depolymerization of selected samples discarded <jats:italic>M<\/jats:italic><jats:sub>w<\/jats:sub> as the key factor in the antitumor activity. Significant differences in sulfates position and branching are observed, presenting FE 2 the higher branching degree. Based on all these experimental data, it is believed that these last two properties are the ones that influence the cytotoxic effects of fucoidan extracts.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/mabi201600340-abs-0001-m.png\"><jats:alt-text>image<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>","DOI":"10.1002\/mabi.201600340","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T12:32:53Z","timestamp":1482237173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity"],"prefix":"10.1002","volume":"17","author":[{"given":"Catarina","family":"Oliveira","sequence":"first","affiliation":[{"name":"3B's Research Group\u2013Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"}]},{"given":"Andreia S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry University of Aveiro  Campus de Santiago 3810\u2010193 Aveiro Portugal"}]},{"given":"Ramon","family":"Novoa\u2010Carballal","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2013Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"}]},{"given":"Cl\u00e1udia","family":"Nunes","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry University of Aveiro  Campus de Santiago 3810\u2010193 Aveiro Portugal"},{"name":"CICECO, Department of Chemistry University of Aveiro  Campus de Santiago 3810\u2010193 Aveiro Portugal"}]},{"given":"Iva","family":"Pashkuleva","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2013Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"}]},{"given":"Nuno M.","family":"Neves","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2013Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"}]},{"given":"Manuel A.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry University of Aveiro  Campus de Santiago 3810\u2010193 Aveiro Portugal"}]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2013Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"}]},{"given":"Albino","family":"Martins","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2013Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"}]},{"given":"Tiago H.","family":"Silva","sequence":"additional","affiliation":[{"name":"3B's Research Group\u2013Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine  AvePark, Parque de Ci\u00eancia e Tecnologia 4805\u2010017 Barco Guimar\u00e3es Portugal"},{"name":"ICVS\/3B's PT Government Associate Laboratory  Braga\/Guimar\u00e3es Portugal"}]}],"member":"311","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"e_1_2_7_1_1","volume-title":"The Cell \u2010 A Molecular Approach","author":"Cooper G. M.","year":"2000"},{"key":"e_1_2_7_2_1","first-page":"282570","volume":"2012","author":"Sak K.","year":"2012","journal-title":"Chemother. Res. Pract."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758834011413423"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21203"},{"key":"e_1_2_7_5_1","unstructured":"National Collaborating Centre for Cancer U. National Collaborating Centre for Cancer UK2009."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.103929"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2317"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13042327"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743280412Y.0000000002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13095920"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11061961"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.12.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13081671"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/md9102106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12094898"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2011.05.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3489"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11082982"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11010081"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050624"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.06.030"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12020851"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB01634G"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13042327"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13081671"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwq046"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2005.11.009"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01478-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)00314-1"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwn085"},{"key":"e_1_2_7_31_1","first-page":"768323","volume":"2014","author":"Moghadamtousi S. Z.","year":"2014","journal-title":"Sci. World. J."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3744"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.116392"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2889"},{"key":"e_1_2_7_35_1","first-page":"3071","volume":"57","author":"Levenson A. S.","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11114267"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar700108g"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2008.08.006"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.05.002"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25424"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0195"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2010.05.021"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(00)90980-7"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006945618657"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(93)90092-L"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199805)40:2<275::AID-JBM12>3.0.CO;2-P"},{"key":"e_1_2_7_47_1","first-page":"2011","volume":"13","author":"Ellouali M.","year":"1993","journal-title":"Anticancer Res."},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2011.08.027"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0780312"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0840106"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(98)00104-9"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2008.11.012"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(84)85242-8"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2012.09.016"}],"container-title":["Macromolecular Bioscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201600340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmabi.201600340","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mabi.201600340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:19:17Z","timestamp":1696519157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201600340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/mabi.201600340"],"URL":"https:\/\/doi.org\/10.1002\/mabi.201600340","archive":["Portico"],"relation":{},"ISSN":["1616-5187","1616-5195"],"issn-type":[{"value":"1616-5187","type":"print"},{"value":"1616-5195","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]},"article-number":"1600340"}}