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To this aim, initially the photo\u2010crosslinkable methacrylated silk fibroin (SF\u2010MA) biopolymer and methacrylated hollow mesoporous silica microcapsules (HMSC\u2010MA) as the main constituents of the novel composite aerogels were synthesized. Afterward, by incorporation of drug\u2010loaded HMSC\u2010MA into the self\u2010assembled SF\u2010MA, printable gel\u2010based composite inks are developed. By exploiting micro\u2010extrusion\u2010based three\u2010dimensional (3D) printing, SF\u2010MA\u2010HMSC composite gels are printed by careful controlling their viscosity to provide a means to control the shape fidelity of the resulted printed gel constructs. The developed scaffold has shown a multitude of interesting biophysical and biological performances. Namely, thanks to the photo\u2010crosslinking of the gel components during the 3D printing, the scaffolds become mechanically more stable than the pristine SF scaffolds. Also, freeze\u2010casting the printed constructs generates further interconnectivity in the printed pore struts resulting in the scaffolds with hierarchically organized porosities necessary for cell infiltration and growth. Importantly, HMSC incorporated scaffolds promote antibacterial drug delivery, cellular ingrowth and proliferation, promoting osteoblastic differentiation by inducing the expression of osteogenic markers and matrix mineralization. Finally, the osteoconductive, \u2010inductive, and anti\u2010infective composite aerogels are expected to act as excellent bone implanting materials with an extra feature of local and sustained release of drug for efficient therapy of bone\u2010related diseases.<\/jats:p>","DOI":"10.1002\/mabi.202100442","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T09:08:31Z","timestamp":1642151311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Fabrication of Antibacterial, Osteo\u2010Inductor 3D Printed Aerogel\u2010Based Scaffolds by Incorporation of Drug Laden Hollow Mesoporous Silica Microparticles into the Self\u2010Assembled Silk Fibroin Biopolymer"],"prefix":"10.1002","volume":"22","author":[{"given":"Philipp","family":"Ng","sequence":"first","affiliation":[{"name":"Institute of Inorganic Chemistry Department of Chemistry University of Cologne  Greinstra\u00dfe 6 50939 Cologne 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