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However, the successful development of muscle remains a significant challenge in the tissue engineering field. Muscle tissue engineering aims to combine muscle precursor cells aligned within a highly organized 3D structure and biological factors crucial to support cell differentiation and maturation into functional myotubes and myofibers. In this study, the use of 3D bioprinting is proposed for the fabrication of muscle tissues using gelatin methacryloyl (GelMA) incorporating sustained insulin\u2010like growth factor\u20101 (IGF\u20101)\u2010releasing microparticles and myoblast cells. This study hypothesizes that functional and mature myotubes will be obtained more efficiently using a bioink that can release IGF\u20101 sustainably for in vitro muscle engineering. Synthesized microfluidic\u2010assisted polymeric microparticles demonstrate successful adsorption of IGF\u20101 and sustained release of IGF\u20101 at physiological pH for at least 21\u00a0days. Incorporating the IGF\u20101\u2010releasing microparticles in the GelMA bioink assisted in promoting the alignment of myoblasts and differentiation into myotubes. Furthermore, the myotubes show spontaneous contraction in the muscle constructs bioprinted with IGF\u20101\u2010releasing bioink. The proposed bioprinting strategy aims to improve the development of new therapies applied to the regeneration and maturation of muscle tissues.<\/jats:p>","DOI":"10.1002\/mabi.202300276","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T08:50:12Z","timestamp":1691052612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Enhanced Maturation of 3D Bioprinted Skeletal Muscle Tissue Constructs Encapsulating Soluble Factor\u2010Releasing Microparticles"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-4110","authenticated-orcid":false,"given":"Natan Roberto","family":"de Barros","sequence":"first","affiliation":[{"name":"Terasaki Institute for Biomedical Innovation (TIBI)  Los Angeles CA 90064 USA"}]},{"given":"Mohammad Ali","family":"Darabi","sequence":"additional","affiliation":[{"name":"Terasaki Institute for Biomedical Innovation (TIBI)  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