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A key requirement is the creation of flexible platforms capable of mimicking human skin features. Here, for the first time, an innovative, highly adaptable electrochemical biosensor with molecularly imprinted polymers (MIPs) is customized for the detection of the inflammatory biomarker interleukin\u20106 (IL\u20106). The 3\u2010electrode gold pattern is geometrically standardized onto a 6\u00a0\u00b5m thick polyimide flexible membrane, an optically transparent, and biocompatible polymeric substrate. Subsequently, a biomimetic sensing layer specifically designed for the detection of IL\u20106 target is produced on these transducers. The obtained MIP biosensor shows a good linear response within the concentration range 50\u00a0pg\u00a0mL<jats:sup>\u22121<\/jats:sup>\u201050\u00a0ng\u00a0mL<jats:sup>\u22121<\/jats:sup>, with a low limit of detection (8\u00a0pg\u00a0mL<jats:sup>\u22121<\/jats:sup>). X\u2010ray photoelectron spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy characterizations confirm the modifications of the flexible gold transducer. After optimization, the biosensing device shows remarkable potential in terms of sensitivity, selectivity, and reproducibility. Overall, the integration of a low\u2010cost electrochemical sensor on biocompatible flexible polymers opens the way for a new generation of monitoring tools with higher accuracy, less invasiveness, and greater patient comfort.<\/jats:p>","DOI":"10.1002\/mabi.202400287","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T18:04:39Z","timestamp":1726682679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Flexible, Electrochemical Skin\u2010Like Platform for Inflammatory Biomarker Monitoring"],"prefix":"10.1002","volume":"24","author":[{"given":"Carolina","family":"Louren\u00e7o","sequence":"first","affiliation":[{"name":"BioMark@ISEP School of Engineering of Polytechnique School of Porto  Porto 4200\u2010072 Portugal"},{"name":"CENIMAT|i3N Department of Materials Science School of Science and Technology NOVA University Lisbon and CEMOP\/UNINOVA  Caparica 2829\u2010516 Portugal"}]},{"given":"Felismina","family":"Moreira","sequence":"additional","affiliation":[{"name":"BioMark@ISEP School of Engineering of Polytechnique School of Porto  Porto 4200\u2010072 Portugal"},{"name":"LABBELS\/CEB Centre of Biological Engineering University of Minho  Braga 4710\u2010057 Portugal"},{"name":"LabRISE\u2010CIETI School of Engineering of Polytechnique School of Porto  Porto 4200\u2010072 Portugal"}]},{"given":"Rui","family":"Igreja","sequence":"additional","affiliation":[{"name":"CENIMAT|i3N Department of Materials Science School of Science and Technology NOVA University Lisbon and CEMOP\/UNINOVA  Caparica 2829\u2010516 Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-1526","authenticated-orcid":false,"given":"Gabriela","family":"Martins","sequence":"additional","affiliation":[{"name":"BioMark@ISEP School of Engineering of Polytechnique School of Porto  Porto 4200\u2010072 Portugal"},{"name":"LABBELS\/CEB Centre of Biological Engineering University of Minho  Braga 4710\u2010057 Portugal"},{"name":"LabRISE\u2010CIETI School of Engineering of Polytechnique School of Porto  Porto 4200\u2010072 Portugal"}]}],"member":"311","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201730"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01659"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201605271"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2013.2295817"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2018.06.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios12020072"},{"key":"e_1_2_8_7_1","first-page":"1039","volume":"2","author":"dos Santos A.","year":"2018","journal-title":"Proc. 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