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To overcome this challenge, this research focuses on developing a carrier that has been modified to possess amphiphilic properties while remaining biodegradable and biocompatible. Amphiphilic esters derived from poly(\u03b3\u2010glutamic acid) by modifying the carboxylate side groups with 4\u2010phenyl\u2010butyl bromide were prepared. These copolymers self\u2010assembled into nanoparticles via nanoprecipitation. The cytocompatibility of the nanoparticles was assessed through lactate dehydrogenase release and metabolic activity of U\u201087 glioma cells. Fluorescein isothiocyanate labeling demonstrated effective cellular uptake of nanoparticles. These nanoparticles were further decorated with polyethylene glycol (PEG) and a PEG\u2010folic acid conjugate (FA\u2010PEG\u2010NH<jats:sub>2<\/jats:sub>), their sizes being 174 and 156\u00a0nm, respectively. Successful grafting was confirmed through <jats:sup>1<\/jats:sup>H\u2010NMR and FTIR spectroscopy. The nanoparticles were loaded with doxorubicin, and release studies showed their sensitivity to the pH of the environment, the encapsulated drug being released faster at pH 4.2 compared to pH 7.4. Encapsulated doxorubicin's effect on U\u201087 cells was tested at various concentrations and time points, showing significantly better performance compared to free doxorubicin. These results suggest that those poly(\u03b3\u2010glutamic acid) derivatives hold great promise for improving the delivery of hydrophobic drugs and enhancing cancer treatment.<\/jats:p>","DOI":"10.1002\/mabi.202500090","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T09:56:07Z","timestamp":1751190967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Amphiphilic Poly(\u03b3\u2010glutamic acid) Derivatives for Delivering Doxorubicin in Cancer Cells"],"prefix":"10.1002","volume":"25","author":[{"given":"Porochista","family":"Dorost","sequence":"first","affiliation":[{"name":"Departament d\u00b4Enginyeria Qu\u00edmica Universitat Polit\u00e8cnica de Catalunya ETSEIB  Barcelona Spain"}]},{"given":"Miguel R. 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