{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:27:02Z","timestamp":1773293222286,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L014904\/1"],"award-info":[{"award-number":["EP\/L014904\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011889","name":"Diamond Light Source","doi-asserted-by":"publisher","award":["MT14877\u20101"],"award-info":[{"award-number":["MT14877\u20101"]}],"id":[{"id":"10.13039\/100011889","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macro Materials &amp;amp; Eng"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>3D printing techniques are utilized to produce biomaterial scaffolds with porous architectures that enable cell attachment, biological factors, and appropriate mechanical strength. As the basic building block of a scaffold, the individual filaments should have sufficient mechanical properties, comprising high compressive loading, and fracture resistance to mimic the natural tissue organisation. In this contribution, process\u2013structure\u2013property relationships in melt extruded polycaprolactone filaments are investigated by considering crystalline features, tensile properties, and an array of processing parameters. The tensile properties of the filaments are improved significantly with relatively higher screw rotational speed and relatively lower processing temperature resulting in considerable increase in Young's modulus. The favorable properties are attributed to the increased crystal volume fraction and anisotropy. Thus, this study provides initial pathways for the potential control of mechanical properties of bioscaffolds via engineering crystalline structural features in printed filaments.<\/jats:p>","DOI":"10.1002\/mame.201800173","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T20:43:38Z","timestamp":1527626618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Process\u2010Driven Microstructure Control in Melt\u2010Extrusion\u2010Based 3D Printing for Tailorable Mechanical Properties in a Polycaprolactone Filament"],"prefix":"10.1002","volume":"303","author":[{"given":"Fengyuan","family":"Liu","sequence":"first","affiliation":[{"name":"School of Mechanical Aerospace and Civil Engineering University of Manchester  Oxford, Road Manchester M13 9PL UK"}]},{"given":"Cian","family":"Vyas","sequence":"additional","affiliation":[{"name":"School of Mechanical Aerospace and Civil Engineering University of Manchester  Oxford, Road Manchester M13 9PL UK"}]},{"given":"Gowsihan","family":"Poologasundarampillai","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Birmingham  Birmingham B5 7EG UK"}]},{"given":"Ian","family":"Pape","sequence":"additional","affiliation":[{"name":"Diamond Light Source  Didcot Oxfordshire OX11 0DE UK"}]},{"given":"Srichand","family":"Hinduja","sequence":"additional","affiliation":[{"name":"School of Mechanical Aerospace and Civil Engineering University of Manchester  Oxford, Road Manchester M13 9PL UK"}]},{"given":"Wajira","family":"Mirihanage","sequence":"additional","affiliation":[{"name":"School of Materials University of Manchester  Oxford Road Manchester M13 9PL UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3683-726X","authenticated-orcid":false,"given":"Paulo J.","family":"Bartolo","sequence":"additional","affiliation":[{"name":"School of Mechanical Aerospace and Civil Engineering University of Manchester  Oxford, Road Manchester M13 9PL UK"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3413"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2004.1466"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2138\/rmg.2006.64.8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2007.05.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-matsci-070909-104427"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6BM00068A"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-100752-5.00013-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.11.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201403354"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0126"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2014.02.057"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2017.01.079"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00829A"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118810408.ch5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2958"},{"key":"e_1_2_7_16_1","first-page":"637","volume-title":"IFMBE Proc.","author":"Packianather M. S.","year":"2017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081607"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.07.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2017.05.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-016-1687-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma9120992"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.38235"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-014-5360-8"},{"key":"e_1_2_7_24_1","first-page":"204","volume":"2","author":"Wang W.","year":"2016","journal-title":"Int. J. Bioprint."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/17452759.2016.1274490"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2009.03.013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compscitech.2010.01.010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201700494"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procir.2017.04.030"},{"key":"e_1_2_7_30_1","author":"Liu F.","year":"2018","journal-title":"CIRP Ann. Manuf. Technol."},{"key":"e_1_2_7_31_1","author":"Liu F.","year":"2018","journal-title":"3D Printing and Additive Manufacturing"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.064"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5082\/5\/2\/025005"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33101"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)NM.2153-5477.0000133"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma502345p"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1051\/mfreview\/2016020"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.22247"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma000243b"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma300363b"}],"container-title":["Macromolecular Materials and Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmame.201800173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mame.201800173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T17:09:38Z","timestamp":1694970578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mame.201800173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/mame.201800173"],"URL":"https:\/\/doi.org\/10.1002\/mame.201800173","archive":["Portico"],"relation":{},"ISSN":["1438-7492","1439-2054"],"issn-type":[{"value":"1438-7492","type":"print"},{"value":"1439-2054","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,29]]},"assertion":[{"value":"2018-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1800173"}}