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Besides being biocompatible, they can be tailored to have required properties and functionalities for this application. Recently, fibrillar biobased nanostructures prove to be valuable in the development of functional biomaterials for tissue regeneration applications. Here, periodate\u2010oxidized nanofibrillated cellulose (OxNFC) is blended with lysozyme amyloid nanofibrils (LNFs) to prepare a self\u2010crosslinkable patch for myocardial implantation. The OxNFC:LNFs patch shows superior wet mechanical properties (60\u00a0MPa for Young's modulus and 1.5\u00a0MPa for tensile stress at tensile strength), antioxidant activity (70% scavenging activity under 24\u00a0h), and bioresorbability ratio (80% under 91 days), when compared to the patches composed solely of NFC or OxNFC. These improvements are achieved while preserving the morphology, required thermal stability for sterilization, and biocompatibility toward rat cardiomyoblast cells. Additionally, both OxNFC and OxNFC:LNFs patches reveal the ability to act as efficient vehicles to deliver spermine modified acetalated dextran nanoparticles, loaded with small interfering RNA, with 80% of delivery after 5 days. This study highlights the value of simply blending OxNFC and LNFs, synergistically combining their key properties and functionalities, resulting in a biopolymeric patch that comprises valuable characteristics for myocardial regeneration applications.<\/jats:p>","DOI":"10.1002\/marc.202400129","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T06:53:44Z","timestamp":1716447224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Implantable Patch of Oxidized Nanofibrillated Cellulose and Lysozyme Amyloid Nanofibrils for the Regeneration of Infarcted Myocardium Tissue and Local Delivery of RNA\u2010Loaded Nanoparticles"],"prefix":"10.1002","volume":"45","author":[{"given":"Tiago","family":"Carvalho","sequence":"first","affiliation":[{"name":"CICECO\u2013Aveiro Institute of Materials Department of Chemistry University of Aveiro Campus de Santiago  Aveiro 3810\u2010193 Portugal"},{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"given":"Raquel","family":"B\u00e1rtolo","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomedical Technology, PRECISION \u2010 Personalized medicine Research Institute University Medical Center Groningen (UMCG), University of Groningen  Ant. Deusinglaan 1 Groningen 9713 AV The Netherlands"}]},{"given":"Alexandra","family":"Correia","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"given":"Carla","family":"Vilela","sequence":"additional","affiliation":[{"name":"CICECO\u2013Aveiro Institute of Materials Department of Chemistry University of Aveiro Campus de Santiago  Aveiro 3810\u2010193 Portugal"}]},{"given":"Shiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-6309","authenticated-orcid":false,"given":"H\u00e9lder A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"},{"name":"Department of Biomaterials and Biomedical Technology, PRECISION \u2010 Personalized medicine Research Institute University Medical Center Groningen (UMCG), University of Groningen  Ant. 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