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Rapid Commun."],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Core\u2013shell tecto dendrimers (CSTDs) with excellent physicochemical properties and good tumor penetration and gene transfection efficiency have been demonstrated to have the potential to replace high\u2010generation dendrimers in biomedical applications. However, their characterization and related biological properties of CSTDs for enhanced tumor penetration and gene delivery still lack in\u2010depth investigation. Herein, three types of dual\u2010responsive CSTDs are designed for thorough physicochemical characterization and investigation of their tumor penetration and gene delivery efficiency. Three types of CSTDs are prepared through phenylborate ester bonds of phenylboronic acid (PBA)\u2010decorated generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers as cores and monose (galactose, glucose, or mannose)\u2010conjugated G3 PAMAM dendrimers as shells and thoroughly characterized via NMR and other techniques. It is shown that the produced CSTDs display strong correlation signals between the PBA and monose protons, similar hydrodynamic diameters, and dual reactive oxygen species\u2010 and pH\u2010responsivenesses. The dual\u2010responsive CSTDs are proven to have structure\u2010dependent tumor penetration property and gene delivery efficiency in terms of small interference RNA for gene silencing and plasmid DNA for gene editing, thus revealing a great potential for different biomedical applications.<\/jats:p>","DOI":"10.1002\/marc.202400251","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T11:19:34Z","timestamp":1717067974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Structural and Property Characterizations of Dual\u2010Responsive Core\u2013Shell Tecto Dendrimers for Tumor Penetration and Gene Delivery Applications"],"prefix":"10.1002","volume":"45","author":[{"given":"Junjie","family":"Liu","sequence":"first","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University  Jinan Shandong 250117 P. R. China"},{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 P. R. China"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University  Jinan Shandong 250117 P. R. China"}]},{"given":"Xiaolei","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University  Jinan Shandong 250117 P. R. 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China"}]},{"given":"Istv\u00e1n","family":"B\u00e1nyai","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry University of Debrecen  Debrecen H\u20104032 Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-6645","authenticated-orcid":false,"given":"Xiangyang","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai 201620 P. R. China"}]},{"given":"Cong","family":"Song","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University  Jinan Shandong 250117 P. R. 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