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Different water soluble co\u2010monomers were present in the initial mixture (e.g. N\u2010isopropylacrylamide and acrylic acid) as well as crosslinkers with different functionalities. Different operating conditions such as polymerization temperature, monomers dilution, neutralization and the initial ratios of co\u2010monomers and monomers\/crosslinker were also tried. Hydrogel particles were produced considering classical free\u2010radical polymerization (FRP) and also RAFT polymerization. Commercially available RAFT agents 4\u2010cyano\u20104\u2010phenylcarbonothioylthio\u2010pentanoic acid (CPA), 2\u2010(dodecylthiocarbonothioylthio)\u20102\u2010methylpropionic acid (DDMAT) and cyanomethyl dodecyl trithiocarbonate (CDT) were alternatively used. Sampling at different polymerization times allowed the study of the kinetics of polymerization through the analysis by SEC of the soluble phase. A tetra\u2010detector array with simultaneous detection of refractive index, light scattering, intrinsic viscosity and ultra\u2010violet signals was used in these studies. Usefulness of <jats:italic>in\u2010line<\/jats:italic> FTIR\u2010ATR monitoring to study the building process of such networks was also assessed. The performance of hydrogel beads was studied through drug delivery tests triggered by changes in the environmental temperature and pH. This research aims to contribute for the elucidation of the connection between the synthesis conditions, molecular architecture and properties\/performance of such advanced materials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/masy.201300045","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T07:41:29Z","timestamp":1385710889000},"page":"41-54","source":"Crossref","is-referenced-by-count":22,"title":["Stimuli\u2010<scp>R<\/scp>esponsive Hydrogels Synthesis using Free Radical and <scp>RAFT<\/scp> Polymerization"],"prefix":"10.1002","volume":"333","author":[{"given":"Miguel A. 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