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These mediators present numerous redundancies of functions, allowing a broad and effective inflammatory response, but simultaneously make the understanding of inflammation pathways much difficult. The extent of the inflammatory response is usually self\u2010limited, although it depends on the balance between the pro\u2010 and anti\u2010inflammatory signals. When that equilibrium is dislocated, a more widespread inflammatory response may take place. Flavonoids have been shown to be possible alternatives to the traditionally molecules used as anti\u2010inflammatory agents. In fact, the biological activities of flavonoids include the modulation of the diverse phases of inflammatory processes, from the gene transcription and expression to the inhibition of the enzymatic activities and the scavenging of the reactive species. In the present review, the inflammatory network is widely revised and the flavonoids\u2019 broad spectrum of action in many of the analyzed inflammatory pathways is revised. This kind of integrated revision is original in the field, providing the reader the simultaneous comprehension of the inflammatory process and the potential beneficial activities of flavonoids.<\/jats:p>","DOI":"10.1002\/med.21347","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T06:57:17Z","timestamp":1430377037000},"page":"877-936","source":"Crossref","is-referenced-by-count":118,"title":["Proinflammatory Pathways: The Modulation by Flavonoids"],"prefix":"10.1002","volume":"35","author":[{"given":"Daniela","family":"Ribeiro","sequence":"first","affiliation":[{"name":"UCIBIO\u2010REQUIMTE, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia Universidade do Porto  4050\u2010313 Porto Portugal"}]},{"given":"Marisa","family":"Freitas","sequence":"additional","affiliation":[{"name":"UCIBIO\u2010REQUIMTE, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia Universidade do Porto  4050\u2010313 Porto Portugal"}]},{"given":"Jos\u00e9 L. 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